Evidence map›Paper›PMID 37129223›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2023

Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization.

Nicole V Tolan, Matthew D Krasowski, Patrick C Mathias, Joesph R Wiencek, Nikolina Babic, Peter R Chai, Allison B Chambliss, Ibrahim Choucair, Christiana A Demetriou, Timothy B Erickson and 17 more

Open access · greenAbstract read
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Cannabinoids and the Gastrointestinal Tract.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 2 countries.

Nicole V TolanDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7239-1843
Matthew D KrasowskiDepartment of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Patrick C MathiasDepartment of Laboratory Medicine and Pathology, Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle, WA, USA.
Joesph R WiencekDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Nikolina BabicDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
Peter R ChaiHarvard Medical School, Boston, MA, USA.ORCID 0000-0003-0955-4117
Allison B ChamblissDepartment of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID 0000-0002-0461-8137
Ibrahim ChoucairDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Christiana A DemetriouDepartment of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus, USA.
Timothy B EricksonHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-1809-4805
Matthew FeldhammerDepartment of Pathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA.
Deborah FrenchDepartment of Laboratory Medicine, University of San Francisco, San Francisco, CA, USA.
Bryan D HayesHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-7349-6770
Phillip KangDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Joe M El-KhouryDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Claire E KnezevicJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew MonteUniversity of Colorado Anschutz, Aurora, CO, USA.
Robert D NerenzDepartment of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Anthony O OkoroduduUniversity of Texas Medical Branch, Galveston, TX, USA.
Stephen M RoperDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Alec SaitmanProvidence Regional Laboratories, Portland, OR, USA.
Vamsi ThiriveedhiDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Sacha N UljonHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-5190-6652
Alexis VestUniversity of Colorado Anschutz, Aurora, CO, USA.
Alison WoodworthDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.
Min YuDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.
Stacy E F MelansonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4209-6085
Brigham and Women's Hospital · USHarvard University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Kentucky · USYale University · USDartmouth–Hitchcock Medical Center · USJohns Hopkins University · USMedical University of South Carolina · USProvidence College · USThe University of Texas Medical Branch at Galveston · USUniversity of Florida · USUniversity of Iowa Hospitals and Clinics · USUniversity of Nicosia · CYUniversity of San Francisco · USUniversity of Southern California · USUniversity of Washington · USVanderbilt University · USWashington University in St. Louis · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002535
6 · The paper itself

Abstract

backgroundMany states in the United States have progressed towards legalization of marijuana including decriminalization, medicinal and/or recreational use. We studied the impact of legalization on cannabis-related emergency department visits in states with varying degrees of legalization.

methodsSeventeen healthcare institutions in fifteen states (California, Colorado, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts, Missouri, New Hampshire, Oregon, South Carolina, Tennessee, Texas, Washington) participated. Cannabinoid immunoassay results and cannabis-related International Classification of Diseases (ninth and tenth versions) codes were obtained for emergency department visits over a 3- to 8-year period during various stages of legalization: no state laws, decriminalized, medical approval before dispensaries, medical dispensaries available, recreational approval before dispensaries and recreational dispensaries available. Trends and monthly rates of cannabinoid immunoassay and cannabis-related International Classification of Diseases code positivity were determined during these legalization periods.

resultsFor most states, there was a significant increase in both cannabinoid immunoassay and International Classification of Diseases code positivity as legalization progressed; however, positivity rates differed. The availability of dispensaries may impact positivity in states with medical and/or recreational approval. In most states with no laws, there was a significant but smaller increase in cannabinoid immunoassay positivity rates.

conclusionsStates may experience an increase in cannabis-related emergency department visits with progression toward marijuana legalization. The differences between states, including those in which no impact was seen, are likely multifactorial and include cultural norms, attitudes of local law enforcement, differing patient populations, legalization in surrounding states, availability of dispensaries, various ordering protocols in the emergency department, and the prevalence of non-regulated cannabis products.

Indexed as

CannabinoidsCannabisMedical MarijuanaColoradoEmergency Service, HospitalHumansLegislation, DrugUnited StatesCannabinoidsMedical MarijuanacannabisdecriminalizationICD codeslegalizationMarijuanarecreational useTetrahydrocannabinolurine drug screen

Identifiers

PMID37129223
PMCPMC10793079
OpenAlexW4367669040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.