Evidence map›Paper›PMID 37128996›Full record

ArticleTherapeutic advances in respiratory disease

The role of prone positioning in patients with SARS-CoV-2-related respiratory failure in non-intensive care unit.

Mara Graziani, Greta Barbieri, Giorgio Maraziti, Marco Falcone, Anna Fiaccadori, Francesco Corradi, Lorenzo Ghiadoni, Katarzyna Satula, Ghislaine Noumi, Cecilia Becattini

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mara GrazianiInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Via Corcianese 130, Perugia, Italy.ORCID 0000-0002-9665-912X
Greta BarbieriDepartment of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.
Giorgio MarazitiInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Marco FalconeInfectious Disease Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Anna FiaccadoriInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Francesco CorradiDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Lorenzo GhiadoniEmergency Medicine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.
Katarzyna SatulaInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Ghislaine NoumiInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Cecilia BecattiniInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProne positioning (PP) is an established and commonly used lung recruitment method for intubated patients with severe acute respiratory distress syndrome, with potential benefits in clinical outcome. The role of PP outside the intensive care unit (ICU) setting is debated.

objectivesWe aimed at assessing the role of PP in death and ICU admission in non-intubated patients with acute respiratory failure related to COronaVIrus Disease-19 (COVID-19) pneumonia.

designThis is a retrospective analysis of a collaborative multicenter database obtained by merging local non-interventional cohorts.

methodsConsecutive adult patients with COVID-19-related respiratory failure were included in a collaborative cohort and classified based on the severity of respiratory failure according to the partial arterial oxygen pressure to fraction of inspired oxygen ratio (PaO

resultsPP was used in 114 of 536 study patients (21.8%), more commonly in patients with lower PaO

conclusionPP is used in a non-negligible proportion of non-intubated patients with COVID-19-related severe respiratory failure and is not associated with death but with ICU admission. The role of PP in this setting merits further evaluation in randomized studies.

Indexed as

COVID-19Respiratory Distress SyndromeRespiratory InsufficiencyAdultHospital MortalityHumansIntensive Care UnitsOxygenProne PositionRespiration, ArtificialRetrospective StudiesSARS-CoV-2OxygenARDSCOVID-19hypoxemic respiratory failurenon-invasive mechanical ventilationprone positioningSARS-CoV2

Identifiers

PMID37128996
PMCPMC10140778

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.