Evidence map›Paper›PMID 37128947›Full record

ReviewExpert review of anti-infective therapy2023

Updated considerations in the diagnosis and management of tuberculosis infection and disease: integrating the latest evidence-based strategies.

Daniel S Graciaa, Marcos Coutinho Schechter, Krystle B Fetalvero, Lisa Marie Cranmer, Russell R Kempker, Kenneth G Castro

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of anti-infective therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Circadian considerations in antimicrobials.European journal of clinical pharmacology · 2026
    Review
  2. Frontiers in cellular and infection microbiology · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Daniel S GraciaaDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Marcos Coutinho SchechterDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Krystle B FetalveroTB-HIV Research Unit, Angelo King Medical Research Center-De La Salle Medical and Health Science Institute, Cavite, Philippines.
Lisa Marie CranmerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Russell R KempkerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Kenneth G CastroDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Emory University · USChildren's Healthcare of Atlanta · USDe La Salle University · PH

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Cavity and Granuloma Oriented Inflammation and Tissue Pharmacokinetics in Pulmonary Tuberculosis (COOK TB)R01AI173946 · NIAID · EMORY UNIVERSITY · PI Russell Ryan Kempker, Brendan Prideaux · 2023 to 2026
$3.1M
The role of antibodies in infant TB preventionK23AI143479 · NIAID · EMORY UNIVERSITY · PI CRANMER, LISA M · 2019 to 2023
$950k
NCATS NIH HHS UL1 TR002378NIAID NIH HHS K23 AI143479NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI173946
6 · The paper itself

Abstract

introductionTuberculosis (TB) is a leading infectious cause of global morbidity and mortality, affecting nearly a quarter of the human population and accounting for over 10 million deaths each year. Over the past several decades, TB incidence and mortality have gradually declined, but 2021 marked a threatening reversal of this trend highlighting the importance of accurate diagnosis and effective treatment of all forms of TB. AREAS COVERED: This review summarizes advances in TB diagnostics, addresses the treatment of people with TB infection and TB disease including recent evidence for treatment regimens for drug-susceptible and drug-resistant TB, and draws attention to special considerations in children and during pregnancy. EXPERT OPINION: Improvements in diagnosis and management of TB have expanded the available options for TB control. Molecular testing has enhanced the detection of TB disease, but better diagnostics are still needed, particularly for certain populations such as children. Novel treatment regimens have shortened treatment and improved outcomes for people with TB. However, important questions remain regarding the optimal management of TB. Work must continue to ensure the potential of the latest developments is realized for all people affected by TB.

Indexed as

Latent TuberculosisTuberculosisTuberculosis, Multidrug-ResistantAntigens, BacterialAntitubercular AgentsChildHumansAntigens, BacterialAntitubercular AgentsdiagnosticsDrug susceptible TBMulti-drug resistant TBTB preventive therapyTuberculosis

Identifiers

PMID37128947
PMCPMC10227769
OpenAlexW4367668360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.