Evidence map›Paper›PMID 37128914›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis-Brief Report.

Shahram Eisa-Beygi, Meng-Ming Hu, Suresh N Kumar, Brooke E Jeffery, Ross F Collery, Nghia Jack Vo, Bhawika S Lamichanne, H Joseph Yost, Matthew B Veldman, Brian A Link

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shahram Eisa-BeygiDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.
Meng-Ming HuDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-0791-5740
Suresh N KumarDepartment of Pathology (S.N.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0001-6479-0046
Brooke E JefferyDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.ORCID 0009-0002-4794-0828
Ross F ColleryDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-1550-299X
Nghia Jack VoDepartment of Radiology (N.V.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-4045-4707
Bhawika S LamichanneMolecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City (B.S.L., H.J.Y.).
H Joseph YostMolecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City (B.S.L., H.J.Y.).
Matthew B VeldmanDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-0328-5916
Brian A LinkDepartment of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-7173-2642
Medical College of Wisconsin · USInstitute of Human Genetics · PLChildren's Hospital of Wisconsin · US

Funding

RPE Signaling in Ocular Health and DiseaseR01EY029267 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 2018 to 2021
$1.8M
NEI NIH HHS R01 EY029267
6 · The paper itself

Abstract

backgroundThe goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation.

methodsHigh resolution and time-lapse imaging of transgenic reporter lines and loss-of-function studies were carried out to study the involvement of mesenchymal stromal cells during venous angiogenesis.

resultsBMP-responsive stromal cells facilitate timely and precise fusion of venous tip cells during developmental angiogenesis.

conclusionsStromal cells are required for anastomosis of venous tip cells in the embryonic caudal hematopoietic tissue.

Indexed as

Bone Morphogenetic ProteinsMesenchymal Stem CellsAnimalsAnimals, Genetically ModifiedCell CommunicationCell FusionStromal CellsBone Morphogenetic Proteinsanastomosisangiogenesisarteriovenous developmentmesenchymal stromal cellszebrafish

Identifiers

PMID37128914
PMCPMC10330147
OpenAlexW4367323439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.