ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023
Percutaneous paravalvular leak closure after transcatheter aortic valve implantation: the international PLUGinTAVI Registry.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Paravalvular Leak After Transcatheter Aortic Valve Implantation: Haemodynamic Consequences, Clinical Impact, and Contemporary Assessment.Journal of cardiovascular development and disease · 2026Review
- Mortality and morbidity benefits of surgical versus transcatheter aortic valve replacement in patients ≤60 years: Findings from a national cohort.JTCVS open · 2026Article
- Amplatzer-Based Transcatheter Paravalvular Leak Closure: A Narrative Review of Device Design, Procedural Strategy, Safety, and Outcomes.Life (Basel, Switzerland) · 2026Review
- Pathophysiology, diagnosis, and management of hemolysis in patients with prosthetic valve related paravalvular leaks.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Review
- Transcatheter Paravalvular Leak Closure: A Step-by-Step Guide.Journal of cardiovascular development and disease · 2026Review
- Paravalvular Leak After Transcatheter Aortic Valve Replacement (TAVR): A Literature Review.Journal of clinical medicine · 2025Review
- Early surgical explantation of a TAVI valve for severe hemolytic anemia caused by mild paravalvular leak.General thoracic and cardiovascular surgery cases · 2025Article
- Paravalvular Leak in Transcatheter Aortic Valve Implantation: A Review of Current Challenges and Future Directions.Journal of cardiovascular development and disease · 2025Review
- Clinically relevant haemolysis after transcatheter aortic valve implantation with new-generation balloon-expandable valve.Open heart · 2025Article
- Clinical Presentation and Percutaneous Treatment of Hemolytic Anemia Associated With Paravalvular Leak After TAVR.JACC. Case reports · 2025Article
- Case Report: Moderate-to-severe paravalvular leak regurgitation after recurrent prosthetic valve endocarditis in a patient with a double-chambered right ventricle associated with a restricted membranous ventricular septal defect.Frontiers in cardiovascular medicine · 2025Article
- Acute Decompensated Valvular Disease in the Intensive Care Unit.JACC. Advances · 2024Review
- Fluid-Solid Interaction Analysis for Developing In-Situ Strain and Flow Sensors for Prosthetic Valve Monitoring.Sensors (Basel, Switzerland) · 2024Article
- Long-Term Outcomes of Aortic Stenosis Patients with Different Flow/Gradient Patterns Undergoing Transcatheter Aortic Valve Implantation.Journal of clinical medicine · 2024Article
- A Machine Learning Model for the Accurate Prediction of 1-Year Survival in TAVI Patients: A Retrospective Observational Cohort Study.Journal of clinical medicine · 2023Article
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Authors and funding
23 authors at 12 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData regarding the safety and long-term effectiveness of percutaneous closure of paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) are scarce.
aimsThis study aims to present a large multicentre international experience of percutaneous post-TAVI PVL closure.
methodsAll patients who underwent percutaneous post-TAVI PVL closure in 14 hospitals across Europe and North America between January 2018 and October 2022 were included.
resultsOverall, 45 patients (64% male) were enrolled. The median age was 80 years (75-84). Among them, 67% and 33% had self-expanding and balloon-expandable valve implantations, respectively. Baseline post-TAVI PVL was severe in 67% of cases and moderate in the rest. The time from index TAVI to PVL closure procedure was 16.1 (8.7-34.8) months. Most patients were in NYHA Class III and IV (73%) before the procedure, and 40% had referred hospitalisations for heart failure between TAVI and the PVL closure procedure. Successful PVL closure was achieved in 94%, reducing regurgitation to ≤mild in 91% and moderate in the rest. The Amplatzer Valvular Plug III was the most frequently used device (27 cases), followed by the Amplatzer Valvular Plug 4. The incidence of severe adverse events was 11%. None of the patients died during the index hospitalisation. During long-term follow-up (21.7±16.2 months), the all-cause mortality rate was 14%, and patients presented improvement in functional status and a significant reduction in the rate of hospitalisation for heart failure (from 40% to 6%).
conclusionsPercutaneous PVL closure is a feasible and safe option for treating post-TAVI leaks. Successful PVL reduction to mild or less could be associated with acute and long-lasting improvements in clinical outcomes.
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