ArticleHeliyon2023
Alteration in ventral tegmental area and default mode network interplay and prediction of coma recovery in patients with sTBI.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the role of VTA and DMN in modulating human consciousness in patient with sTBI. Methods: We mapped an atlas of VTA in the brainstem and a total of 19 region of interests in the ventral and dorsal DMN onto functional magnetic resonance imaging in 28 patients with sTBI and 28 healthy controls. We assessed the functional connectivity alteration in subcortical VTA and cortical DMN nodes in patients of coma. We evaluated the spatially distribution of FC alteration in VTA and DMN nodes after sTBI and evaluated their predictive value for coma recovery. Results: There was a decrease in FC between VTA and DMN in patients compared to controls. After decomposition, the FC between VTA and 10 DMN nodes were decreased whereas the FC within 2 DMN nodes were increased in patients with acute coma. The FC alteration in DMN nodes provided useful information for the early prediction of 6-month coma recovery in patients with sTBI. Conclusions: We provide initial evidence for the decreased FC between VTA and massive DMN nodes in patients with coma in acute phase of sTBI. We found that the FC alteration within DMN is more useful than the FC alteration between VTA and DMN for predicting coma recovery in patients with sTBI. VTA and DMN connectivity mapping provides an opportunity to advance the cortical-subcortical mechanism of human consciousness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.