Evidence map›Paper›PMID 37128132›Full record

ArticlePediatric transplantation2023

CMV-associated collapsing focal segmental glomerulosclerosis after kidney transplant in a pediatric patient.

Madeline F E Parr, Guillermo Hidalgo, Michael J Goldstein, Ibrahim Batal, Kenneth V Lieberman, Marlene R Amoruso, Aryeh Z Baer, Namrata G Jain

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Madeline F E ParrDivision of Pediatric Nephrology, Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0002-2755-1262
Guillermo HidalgoDivision of Pediatric Nephrology, Department of Pediatrics, Jersey Shore University Medical Center, Neptune, New Jersey, USA.ORCID 0000-0002-8003-6913
Michael J GoldsteinDepartment of Transplant Surgery, Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0001-5233-2814
Ibrahim BatalDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-0686-5457
Kenneth V LiebermanDivision of Pediatric Nephrology, Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0002-5772-7708
Marlene R AmorusoDepartment of Transplant Surgery, Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0002-4513-8252
Aryeh Z BaerDivision of Pediatric Infectious Disease, Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0002-2716-8327
Namrata G JainDivision of Pediatric Nephrology, Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA.ORCID 0000-0002-9103-6601
Hackensack University Medical Center · USColumbia University Irving Medical Center · USJersey Shore University Medical Center · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NCATS NIH HHS UL1 TR001873
6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) is a significant cause of morbidity among immunocompromised patients who have undergone kidney transplantation and is known to rarely induce collapsing focal segmental glomerulosclerosis (FSGS) among adults.

methodsWe present the first reported case of CMV-induced collapsing FSGS in a pediatric patient after kidney transplant.

resultsOur patient underwent a deceased donor kidney transplant due to end-stage renal disease secondary to lupus nephritis. Approximately 4 months after transplantation, he developed signs of worsening kidney function in the setting of CMV viremia and was found to have collapsing features of FSGS on kidney transplant biopsy. He was managed with a prompt escalation of antiviral therapy along with a reduction of immunosuppression and recovered without significant complication. At follow-up, he continued to have undetectable CMV titers, creatinine within normal limits, and no significant proteinuria.

conclusionThis report demonstrates CMV as a cause of collapsing FSGS and should be considered among pediatric transplant recipients who present with acute kidney injury, as should early assessment of APOL1 genetic status in both donor and recipient.

Indexed as

Cytomegalovirus InfectionsGlomerulosclerosis, Focal SegmentalKidney Failure, ChronicKidney TransplantationAdultApolipoprotein L1ChildCytomegalovirusHumansMaleAPOL1 protein, humanApolipoprotein L1collapsing focal segmental glomerulosclerosiscytomegaloviruskidney transplantationpediatrics

Identifiers

PMID37128132
PMCPMC10753975
OpenAlexW4367669032

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.