ReviewNature reviews. Chemistry2020
Helical polymers for biological and medical applications.
Review in Nature reviews. Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Proton Transfer Shuttle Mediated Dormant-Active Balance for Accelerated and Controlled Polymerization of N-Carboxyanhydrides.Angewandte Chemie (International ed. in English) · 2026Article
- Meniscal tissue engineering: Bridging clinical needs and experimental innovation.Journal of orthopaedic translation · 2026Review
- Poly(O-Propargyl-N-Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s.Macromolecular rapid communications · 2026Article
- Helix Regulation of Poly(phenylacetylene)s through the Interplay between Enantiomeric Excess and Temperature-Triggered Pendant Isomerization.Precision chemistry · 2025Article
- A hydroxyl group dictates handedness, pitch, and mechanics in a crystalline covalent helical polymer.Science advances · 2025Article
- Self-Assembly of pH-Responsive Star-Shaped Amphiphilic Polypeptides Based on l‑Lysine and l‑Leucine.ACS polymers Au · 2025Article
- Dual dynamic helical poly(disulfide)s with conformational adaptivity and configurational recyclability.Nature chemistry · 2025Article
- Organoid-based tissue engineering for advanced tissue repair and reconstruction.Materials today. Bio · 2025Review
- Helical π-Conjugated Structure Based on Complementary Helical Monomers with Circularly Polarized Luminescence.Organic letters · 2025Article
- Unravelling emergence of chirality in click-chemistry polymers down to the single-chain level.Nature communications · 2025Article
- Amplifying and Reversing the Chiral Bias in Asymmetric Photo-Polymerization Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Helical peptide structure improves conductivity and stability of solid electrolytes.Nature materials · 2024Article
- Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA).ACS macro letters · 2024Article
- Exo-chirality of the α-helix.Nature communications · 2024Article
- Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy.Nature communications · 2024Article
- Characterization of new cellulosic fiber derived fromHeliyon · 2024Article
- Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells.Nature biomedical engineering · 2024Article
- Modulation of supramolecular chirality by stepwise axial coordination in a nano-size trizinc(ii)porphyrin trimer.Chemical science · 2023Article
- Chitosan-based drug delivery systems for skin atopic dermatitis: recent advancements and patent trends.Drug delivery and translational research · 2023Review
- Enhanced Bacterial-Infected Wound Healing by Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with Self-Optimized Cooperative Multi-Point Anchoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helices are the most prevalent secondary structure in biomolecules and play vital roles in their activity. Chemists have been fascinated with mimicking this molecular conformation with synthetic materials. Research has now been devoted to the synthesis and characterization of helical materials, and to understand the design principles behind this molecular architecture. In parallel, work has been done to develop synthetic polymers for biological and medical applications. We now have access to materials with controlled size, molecular conformation, multivalency or functionality. As a result, synthetic polymers are being investigated in areas such as drug and gene delivery, tissue engineering, imaging and sensing, or as polymer therapeutics. Here, we provide a critical view of where these two fields, helical polymers and polymers for biological and medical applications, overlap. We have selected relevant polymer families and examples to illustrate the range of applications that can be targeted and the impact of the helical conformation on the performance. For each family of polymers, we briefly describe how they can be prepared, what helical conformations are observed and what parameters control helicity. We close this Review with an outlook of the challenges ahead, including the characterization of helicity through the process and the identification of biocompatibility.
Identifiers
37127955What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.