Evidence map›Paper›PMID 37127832›Full record

ArticleBrain imaging and behavior2023

Behavioral and biologic characteristics of cancer-related cognitive impairment biotypes.

Michele M Mulholland, Sarah Prinsloo, Elizabeth Kvale, Adrienne N Dula, Oxana Palesh, Shelli R Kesler

Abstract read
In one paragraph

Article in Brain imaging and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Chemotherapy-related cognitive impairment and kidney dysfunction.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michele M MulhollandKeeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.
Sarah PrinslooDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Elizabeth KvaleDepartment of Geriatrics and Palliative Care, Baylor College of Medicine, Houston, TX, USA.
Adrienne N DulaDepartment of Neurology, Dell School of Medicine, The University of Texas at Austin, Austin, TX, USA.
Oxana PaleshDepartment of Psychiatry, Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond,, VA, USA.
Shelli R KeslerDepartment of Geriatrics and Palliative Care, Baylor College of Medicine, Houston, TX, USA. srkesler@austin.utexas.edu.

Funding

Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)R01CA172145 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KESLER, SHELLI R, PALESH, OXANA G · 2012 to 2024
$3.3M
Predicting Long-Term Chemotherapy-Related Cognitive ImpairmentR01CA226080 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI KESLER, SHELLI R, PALESH, OXANA G · 2019 to 2024
$3.1M
NCI NIH HHS R01 CA172145NCI NIH HHS R01 CA226080NIH HHS 1R01CA226080
6 · The paper itself

Abstract

Psychiatric diagnosis is moving away from symptom-based classification and towards multi-dimensional, biologically-based characterization, or biotyping. We previously identified three biotypes of chemotherapy-related cognitive impairment based on functional brain connectivity. In this follow-up study of 80 chemotherapy-treated breast cancer survivors and 80 non-cancer controls, we evaluated additional factors to help explain biotype expression: neurofunctional stability, brain age, apolipoprotein (APOE) genotype, and psychoneurologic symptoms. We also compared the discriminative ability of a traditional, symptom-based cognitive impairment definition with that of biotypes. We found significant differences in cortical brain age (F = 10.50, p < 0.001), neurofunctional stability (F = 2.83, p = 0.041), APOE e4 genotype (X

Indexed as

Biological ProductsCognitive DysfunctionNeoplasmsApolipoproteins EFollow-Up StudiesHumansMagnetic Resonance ImagingApolipoproteins EBiological ProductsBiotypesBreast cancerChemotherapyChemotherapy-related cognitive impairmentNeurofunctional stability

Identifiers

PMID37127832
PMCPMC10195718

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.