ReviewScientific reports2023
Type III Gustilo-Anderson open fracture does not justify routine prophylactic Gram-negative antibiotic coverage.
Review in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Research progress of 3D-printed anti-infective bone tissue engineering scaffolds based on triply periodic minimal surface structures.APL bioengineering · 2026Review
- Article
- Optimizing antibiotic prophylaxis for type III open fractures in China: a cost-effectiveness analysis.Health and quality of life outcomes · 2026Article
- Orthopedic Trauma Management: A Comprehensive Review of Surgical Interventions, Rehabilitation, and Patient Outcomes.Cureus · 2026Review
- Strategies to Prevent Surgical Site Infections in Orthopaedic Surgery: A Literature Review.Cureus · 2025Review
- Fracture-Related Infections: Current Status and Perspectives from the International Society of Antimicrobial Chemotherapy.Antibiotics (Basel, Switzerland) · 2025Review
- Is routine Gram-negative antibiotic coverage required for optimum antibiotic prophylaxis in open reduction and internal fixation of fractures? A multicenter analysis of bacteria pathogens in fracture-related infections.Musculoskeletal surgery · 2025Article
- State of orthopaedic trauma registries in South Korea, Japan, and Australia.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Outcomes Associated with Choice of Prophylactic Antibiotics in Open Fractures.The Journal of bone and joint surgery. American volume · 2025Article
- Association between the generation of cephalosporins for perioperative prophylaxis and postoperative surgical site infections in open fractures: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Comparing piperacillin/tazobactam to current guidelines for the treatment of open fractures: A systematic review.Journal of orthopaedics · 2025Review
- Impact of enhanced recovery after surgery (ERAS) on surgical site infection and postoperative recovery outcomes: a retrospective study of 1276 cases.Scientific reports · 2024Observational
- Distribution of pathogens and risk factors for post-replantation wound infection in patients with traumatic major limb mutilation.PloS one · 2024Article
- A novel primary antibiotic cement-coated locking plate as a temporary fixation for the treatment of open tibial fracture.Scientific reports · 2023Article
- Management of open fractures: A narrative review.Journal of clinical orthopaedics and trauma · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative surgical site infection (SSI) is common in open long bone fractures, so early administration of prophylactic antibiotics is critical to prevent SSI. However, the necessity of initial broad-spectrum coverage for Gram-positive and -negative pathogens remains unclear. The purpose of this study was to clarify the effectiveness of prophylactic broad-spectrum antibiotics in a large, national-wide sample. We reviewed an open fracture database of prospectively collected data from 111 institutions managed by our society. A retrospective cohort study was designed to compare the rates of deep SSI between narrow- and broad-spectrum antibiotics, which were initiated within three hours after injury. A total of 1041 type III fractures were evaluated at three months after injury. Overall deep SSI rates did not differ significantly between the narrow-spectrum group (43/538, 8.0%) and broad-spectrum group (49/503, 9.8%) (p = 0.320). During propensity score-matched analysis, 425 pairs were analyzed. After matching, no significant difference in the SSI rate was seen between the narrow- and broad-spectrum groups, with 42 SSIs (9.9%) and 40 SSIs (9.4%), respectively (p = 0.816). The probability of deep SSI was not reduced by broad-spectrum antibiotics compared with narrow-spectrum antibiotics in type III open long bone fractures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.