ArticleScientific reports2023
Respiratory entrainment of the locus coeruleus modulates arousal level to avoid physical risks from external vibration.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- From Breath to Behavior: Respiratory Features Predict Visual Detection Performance.bioRxiv : the preprint server for biology · 2026Article
- A subject-specific mechanistic model of affect links electroencephalography, cardiorespiratory feedback, and monoaminergic dynamics.Frontiers in computational neuroscience · 2026Article
- Effects of external body vibrations on cognitive performance through brain-cardio-respiratory dynamics.Scientific reports · 2025Article
- The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways.Nature reviews. Cardiology · 2025Review
- Variations of autonomic arousal mediate the reportability of mind blanking occurrences.Scientific reports · 2025Article
- In-silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach.PLoS computational biology · 2024Article
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Authors and funding
6 authors.
Funding
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Abstract
Slow rocking chairs can easily put people to sleep, while violent shaking, such as during earthquakes, may lead to rapid awakening. However, the influence of external body vibrations on arousal remains unclear. Herein, a computational model of a locus coeruleus (LC)-norepinephrine (NE) system and cardio-respiratory system were used to show that respiratory entrainment of the LC modulates arousal levels, which is an adaptation to avoid physical risks from external vibration. External vibrations of sinusoidal waves with different frequencies ranging from 0.1 to 20 [Hz] were applied to the LC based on the results of previous studies. We found that respiratory entrainment of the LC decreased the breathing rate (BR) and heart rate (HR) to maintain the HR within its normal range. Furthermore, 1:1 phase locking enhanced arousal level while phase-amplitude coupling decreased it for larger vibration stimuli. These findings suggest that respiratory entrainment of the LC might automatically modulate cardio-respiratory system homeostasis and arousal levels for performance readiness (fight/flight or freeze) to avoid physical risks from larger external vibrations.
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