Evidence map›Paper›PMID 37127710›Full record

ArticleNature biomedical engineering2023

Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue.

Hongjie Hu, Yuxiang Ma, Xiaoxiang Gao, Dawei Song, Mohan Li, Hao Huang, Xuejun Qian, Ray Wu, Keren Shi, Hong Ding and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  5. A Conformable CMOS Ultrasound System for Point-of-Care Imaging.medRxiv : the preprint server for health sciences · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  12. Article
  13. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Hongjie Hu *Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Yuxiang Ma *Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7731-7255
Xiaoxiang Gao *Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Dawei Song *Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Mohan LiDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Hao HuangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Xuejun QianDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3634-8757
Ray WuDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0561-0508
Keren ShiMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Hong DingDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Muyang LinDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6627-6294
Xiangjun ChenMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Wenbo ZhaoDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-3418-9433
Baiyan QiMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Sai ZhouMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Ruimin ChenDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Yue GuMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0437-5339
Yimu ChenDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Yusheng LeiDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Chonghe WangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Chunfeng WangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Yitian TongDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
Haotian CuiDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-8119-9485
Abdulhameed AbdalDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, USA.
Yangzhi ZhuDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2920-3365
Xinyu TianMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Zhaoxin ChenDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Chengchangfeng LuDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3807-9917
Xinyi YangMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Jing MuMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Zhiyuan LouDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Mohammad EghtedariDepartment of Radiology, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4242-2637
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1527-3020
Assad OberaiDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Sheng XuMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA. shengxu@ucsd.edu.ORCID http://orcid.org/0000-0002-3120-4992

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01EB033464-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R21EB025521-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R21EB027303-01A1U.S. Department of Health & Human Services | National Institutes of Health (NIH) 3R21EB027303-02S1
6 · The paper itself

Abstract

Serial assessment of the biomechanical properties of tissues can be used to aid the early detection and management of pathophysiological conditions, to track the evolution of lesions and to evaluate the progress of rehabilitation. However, current methods are invasive, can be used only for short-term measurements, or have insufficient penetration depth or spatial resolution. Here we describe a stretchable ultrasonic array for performing serial non-invasive elastographic measurements of tissues up to 4 cm beneath the skin at a spatial resolution of 0.5 mm. The array conforms to human skin and acoustically couples with it, allowing for accurate elastographic imaging, which we validated via magnetic resonance elastography. We used the device to map three-dimensional distributions of the Young's modulus of tissues ex vivo, to detect microstructural damage in the muscles of volunteers before the onset of soreness and to monitor the dynamic recovery process of muscle injuries during physiotherapies. The technology may facilitate the diagnosis and treatment of diseases affecting tissue biomechanics.

Indexed as

Elasticity Imaging TechniquesElastic ModulusImaging, Three-DimensionalAdultBiomechanical PhenomenaHumansMagnetic Resonance ImagingMaleMuscle, SkeletalSkin

Identifiers

PMID37127710

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.