Evidence map›Paper›PMID 37127673›Full record

ArticleBMC biotechnology2023

A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility.

Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C Elfar, Manmeet Rawat, Walaa Elfar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Prem Kumar GovindappaDepartment of Orthopaedics and Sports Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Mosammat BegomDepartment of Medicine, The Penn State University College of Medicine, Hershey, PA, 17033, USA.
Yash GuptaDepartment of Medicine, The Penn State University College of Medicine, Hershey, PA, 17033, USA.
John C ElfarDepartment of Orthopaedics and Sports Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Manmeet RawatDepartment of Medicine, The Penn State University College of Medicine, Hershey, PA, 17033, USA. mrawat@pennstatehealth.psu.edu.
Walaa ElfarDepartment of Pediatrics, University of Arizona College of Medicine, Tucson, AZ, 85724, USA. welfar@arizona.edu.
Pennsylvania State University · USUniversity of Arizona · US

Funding

Erythropoietin for NeuroregenerationK08AR060164 · NIAMS · UNIVERSITY OF ROCHESTER · PI ELFAR, JOHN · 2013 to 2017
$578k
NIAMS NIH HHS K08 AR060164
6 · The paper itself

Abstract

backgroundDysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intestine in various injury models. While EPO receptors (EPOR) are present in vagal Schwann cells, the role of EPOR in POI recovery is unknown because of the lack of EPOR antagonists or Schwann-cell specific EPOR knockout animals. This study was designed to explore the effect of EPO via EPOR in vagal nerve Schwann cells in a mouse model of POI.

resultsThe structural features of EPOR and its activation by EPO-mediated dimerization were understood using structural analysis. Later, using the Cre-loxP system, we developed a myelin protein zero (Mpz) promoter-driven knockout mouse model of Schwann cell EPOR (MpzCre-EPOR

conclusionsTo the best of our knowledge, this is the first pre-clinical study to demonstrate a novel mouse model of EPOR specific knock out on Schwan cells with an effect in the gut. We also showed novel beneficial effects of EPO through vagus nerve Schwann cell-EPOR in intestinal dysmotility. Our findings suggest that EPO-EPOR signaling in the vagus nerve after POI is important for the functional recovery of ITT.

Indexed as

ErythropoietinReceptors, ErythropoietinAnimalsGastrointestinal MotilityMiceMice, KnockoutSchwann CellsSignal TransductionErythropoietinReceptors, ErythropoietinEnteric glial cellsErythropoietinErythropoietin receptors knockoutIntestinal manipulationIntestinal transit timePostoperative ileus.Schwann cellsStructural analysisVagus nerve

Identifiers

PMID37127673
PMCPMC10152589
OpenAlexW4367599419

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.