Evidence map›Paper›PMID 37127331›Full record

ArticleGenome research2023

A novel quantitative trait locus implicates

Mikhail O Maksimov, Cynthia Wu, David G Ashbrook, Flavia Villani, Vincenza Colonna, Nima Mousavi, Nichole Ma, Lu Lu, Jonathan K Pritchard, Alon Goren and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genome-wide detection of somatic mosaicism at short tandem repeats.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Mikhail O Maksimov *Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0001-9428-3424
Cynthia Wu *Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0002-3687-2199
David G AshbrookDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.ORCID 0000-0002-7397-8910
Flavia VillaniDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.ORCID 0000-0003-3633-0610
Vincenza ColonnaDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.ORCID 0000-0002-3966-0474
Nima MousaviDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0003-1926-8982
Nichole MaDepartment of Medicine, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0003-4343-8689
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Jonathan K PritchardDepartment of Genetics, Stanford University, Stanford, California 94305, USA.ORCID 0000-0002-8828-5236
Alon GorenDepartment of Medicine, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0001-5669-9357
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Abraham A PalmerInstitute for Genomic Medicine, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0003-3634-0747
Melissa GymrekDepartment of Medicine, University of California San Diego, La Jolla, California 92093, USA; mgymrek@ucsd.edu.ORCID 0000-0002-6086-3903
University of California San Diego · USUniversity of Tennessee Health Science Center · USStanford University · US

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI MEYER, PAUL J · 2014 to 2023
$27.4M
Use for ResourceP40OD011102 · OD · JACKSON LABORATORY · PI Steven Carmen Munger · 2012 to 2026
$15.0M
Integration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3M
Systems Genetics of Alcohol Response and Stress Effects in CNSU01AA013499 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2002 to 2016
$4.8M
Systematic characterization of tandem repeat variants contributing to complex traitsR01HG010885 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alon Goren, Melissa Gymrek · 2020 to 2026
$4.8M
TIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2017 to 2021
$3.9M
The role of structural variants and tandem repeats in substance abuse-related behavioral traitsU01DA051234 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GYMREK, MELISSA, PALMER, ABRAHAM A · 2021 to 2025
$3.5M
INIA-STRESS: Informatics and Analysis CoreU01AA016662 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILLIAMS, ROBERT W. · 2007 to 2016
$2.9M
Genetic Analysis of Ethanol-Mediated Stress ReductionU01AA014425 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU · 2004 to 2008
$2.1M
NHGRI NIH HHS R01 HG008140NIAAA NIH HHS U01 AA013499NIAAA NIH HHS U01 AA014425NIAAA NIH HHS U01 AA016662NIDA NIH HHS P30 DA044223NIDA NIH HHS P50 DA037844NIDA NIH HHS U01 DA051234NIH HHS P40 OD011102
6 · The paper itself

Abstract

Short tandem repeats (STRs) are a class of rapidly mutating genetic elements typically characterized by repeated units of 1-6 bp. We leveraged whole-genome sequencing data for 152 recombinant inbred (RI) strains from the BXD family of mice to map loci that modulate genome-wide patterns of new mutations arising during parent-to-offspring transmission at STRs. We defined quantitative phenotypes describing the numbers and types of germline STR mutations in each strain and performed quantitative trait locus (QTL) analyses for each of these phenotypes. We identified a locus on Chromosome 13 at which strains inheriting the C57BL/6J (

Indexed as

Microsatellite RepeatsQuantitative Trait LociAnimalsHaplotypesMiceMice, Inbred C57BLMice, Inbred DBA

Identifiers

PMID37127331
PMCPMC10317118
OpenAlexW4367608789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.