ArticleProceedings of the National Academy of Sciences of the United States of America2023
Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07477028 (Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Quantum evidence of nonlocal consciousness during clinical death.Innovation (Cambridge (Mass.)) · 2026Article
- Article
- The dying-moment dream hypothesis: heaven and hell as the brain's final dream.Frontiers in psychology · 2026Article
- Self-reported near-death and near-death-like experiences in a Chinese online sample: an exploratory mixed-methods study.Frontiers in psychology · 2026Article
- Palliative General Anesthesia at Terminal Extubation: "Go Gentle into that Good Night".Neurocritical care · 2025Article
- Hypoxia, Psychedelics, and Terminal Lucidity: A Perspective on Neuroplasticity and Neuropsychiatric Disorders.ACS pharmacology & translational science · 2025Review
- Life in Suspension with Death: Biocultural Ontologies, Perceptual Cues, and Biomarkers for the Tibetan Tukdam Postmortem Meditative State.Culture, medicine and psychiatry · 2025Article
- Modeling Emotional Arousal With Turbulence Measured by EEG.Psychophysiology · 2025Article
- Introduction: Embodying a Liberated Mind at Death.Culture, medicine and psychiatry · 2025Article
- A neuroscientific model of near-death experiences.Nature reviews. Neurology · 2025Review
- Consciousness in deep hypothermic circulatory arrest: a feasibility study.Journal of cardiothoracic surgery · 2025Article
- Local field potential changes during euthanasia may parallel with near death experience.Scientific reports · 2025Article
- An encounter with death: a comparative thematic and content analysis of naturalistic DMT experiences and the near-death experience.Frontiers in psychology · 2025Article
- The central clinical relevance of near-death experiences in acute care contexts: identification, prediction, and management.Frontiers in psychology · 2025Article
- The intersection of near-death experiences (NDEs) and traumatic brain injury (TBI): neurobiological, phenomenological, and creative implications.Frontiers in human neuroscience · 2025Article
- Consciousness and the Dying Brain.Anesthesiology · 2024Review
- Near-death experiences after cardiac arrest: a scoping review.Discover mental health · 2024Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The brain is assumed to be hypoactive during cardiac arrest. However, animal models of cardiac and respiratory arrest demonstrate a surge of gamma oscillations and functional connectivity. To investigate whether these preclinical findings translate to humans, we analyzed electroencephalogram and electrocardiogram signals in four comatose dying patients before and after the withdrawal of ventilatory support. Two of the four patients exhibited a rapid and marked surge of gamma power, surge of cross-frequency coupling of gamma waves with slower oscillations, and increased interhemispheric functional and directed connectivity in gamma bands. High-frequency oscillations paralleled the activation of beta/gamma cross-frequency coupling within the somatosensory cortices. Importantly, both patients displayed surges of functional and directed connectivity at multiple frequency bands within the posterior cortical "hot zone," a region postulated to be critical for conscious processing. This gamma activity was stimulated by global hypoxia and surged further as cardiac conditions deteriorated in the dying patients. These data demonstrate that the surge of gamma power and connectivity observed in animal models of cardiac arrest can be observed in select patients during the process of dying.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.