ArticleScience advances2023
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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23citing papers in PubMed, 2 pooled it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.EBioMedicine · 2026Pooled it
- A systematic review of GWAS on CMR imaging traits: genetic insights into cardiovascular structure, function, and diseases.EBioMedicine · 2025Pooled it
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression.Translational psychiatry · 2026Article
- Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases.Life metabolism · 2026Article
- Article
- Addressing Unmet Needs in Heart Failure with Preserved Ejection Fraction: Multi-Omics Approaches to Therapeutic Discovery.International journal of molecular sciences · 2026Review
- Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study.Frontiers in psychiatry · 2026Article
- Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers.BMC medicine · 2025Article
- Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis.Cardiovascular diabetology · 2025Article
- A Mendelian randomization analysis of cardiac MRI measurements as surrogate outcomes for heart failure and atrial fibrillation.Communications medicine · 2025Article
- Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.Nature genetics · 2025Article
- Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function.Clinical epigenetics · 2025Article
- Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction.Nature cardiovascular research · 2025Article
- A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking.Nature human behaviour · 2025Article
- Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis.Chinese medicine · 2024Article
- Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation.Genome medicine · 2024Article
- Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity.Cell biology and toxicology · 2024Article
- Using Omics to Identify Novel Therapeutic Targets in Heart Failure.Circulation. Genomic and precision medicine · 2024Review
Corrections and comments
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Authors and funding
21 authors.
Amand F SchmidtInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0003-1327-0424
Mimount BourfissDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-5820-4610
Abdulrahman AlasiriDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-1450-2936
Esther Puyol-AntonDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK.ORCID 0000-0002-9789-6629
Sandesh ChopadeInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
Marion van VugtInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0002-6634-1989
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratory, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-6888-1404
Christian GrossDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-9482-4259
Chris ClarksonInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
Albert HenryInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0001-7422-2288
Tom R LumbersUCL BHF Research Accelerator Centre, London, UK.ORCID 0000-0002-9077-4741
Pim van der HarstDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-2713-686X
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3409-1110
Birgitta K VelthuisDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-2542-9474
Anneline S J M Te RieleDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-4694-4790
Aroon D HingoraniInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0001-8365-0081
Bram RuijsinkDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-8313-5709
Folkert W AsselbergsInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0002-1692-8669
Jessica van SettenDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-4934-7510
Chris FinanInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.ORCID 0000-0002-3319-1937
Funding
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MBioinformatics Strategies for Genome-Wide Association StudiesR01LM010098 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., WILLIAMS, SCOTT MATTHEW · 2009 to 2023
$5.1MBritish Heart Foundation PG/22/10989Medical Research Council MR/V033867/1NHLBI NIH HHS R01 HL105756NLM NIH HHS R01 LM010098Wellcome Trust
Abstract
Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure.
Indexed as
Atrial FibrillationCardiomyopathy, DilatedHeart FailureNeoplasmsCardiotoxicityGenome-Wide Association StudyGlypicansHumansGlypicansGPC5 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.