Evidence map›Paper›PMID 37126538›Full record

ReviewACS applied bio materials2023

Hydrogels for Mucosal Drug Delivery.

Taj Yeruva, Sydney Yang, Shadin Doski, Gregg A Duncan

Abstract readReview
In one paragraph

Review in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taj YeruvaFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Sydney YangFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Shadin DoskiFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Gregg A DuncanFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0002-6811-1327

Funding

Evaluating Modes of Influenza Transmission using a Randomized Controlled Trial (EMIT-2-RCT)U19AI162130 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SREBRIC, JELENA · 2021 to 2025
$15.2M
Understanding alterations to mucus composition and function in asthmaR01HL160540 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI Gregg Duncan · 2022 to 2026
$2.1M
Synthetic mucus for local therapeutic deliveryR21EB030834 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI DUNCAN, GREGG, MAISEL, KATHARINA · 2021 to 2022
$382k
NHLBI NIH HHS R01 HL160540NIAID NIH HHS U19 AI162130NIBIB NIH HHS R21 EB030834
6 · The paper itself

Abstract

Mucosal tissues are often a desirable site of drug action to treat disease and engage the immune system. However, systemically administered drugs suffer from limited bioavailability in mucosal tissues where technologies to enable direct, local delivery to these sites would prove useful. In this Spotlight on Applications article, we discuss hydrogels as an attractive means for local delivery of therapeutics to address a range of conditions affecting the eye, nose, oral cavity, gastrointestinal, urinary bladder, and vaginal tracts. Considering the barriers to effective mucosal delivery, we provide an overview of the key parameters in the use of hydrogels for these applications. Finally, we highlight recent work demonstrating their use for inflammatory and infectious diseases affecting these tissues.

Indexed as

Drug Delivery SystemsHydrogelsFemaleHumansMucous MembraneHydrogelsdrug deliveryhydrogelsinfectious diseaseinflammatory diseasemucosa

Identifiers

PMID37126538
PMCPMC11966650

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.