Evidence map›Paper›PMID 37126106›Full record

ArticleJournal of cancer research and clinical oncology2023

Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells.

Serkan Kuccukturk, Mehmet Ali Karaselek, Tugce Duran, Ahmed Nuri Kursunlu, Mustafa Ozmen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Serkan KuccukturkMedicine Faculty, Department of Medical Biology, Karamanoglu Mehmetbey University, 70100, Karaman, Turkey.
Mehmet Ali KaraselekMeram School of Medicine, Department of Internal Medicine, Necmettin Erbakan University, 42080, Konya, Turkey.
Tugce DuranMedicine Faculty, Department of Medical Genetic, KTO Karatay University, 42020, Konya, Turkey.
Ahmed Nuri KursunluScience Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey.
Mustafa OzmenScience Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey. musozmen@gmail.com.
Selçuk University · TRKaramanoğlu Mehmetbey University · TRKTO Karatay University · TRNecmettin Erbakan University · TR

Funding

Necmettin Erbakan Üniversitesi 221218015
6 · The paper itself

Abstract

purposeThis study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells. MATERIALS AND

methodsThe MTT method was used to determine the IC

resultsThe results showed that the d-Q-P5 and p-Q-P5 effectively inhibited the proliferation of the cells by upregulating proapoptotic genes (Bax, Bad, p53, Bak, and Apaf-1) and genes involved in the caspase pathway (Casp2, Casp3, and Casp9), while downregulating the antiapoptotic gene (Bcl-2).

conclusionsThis study is the first to demonstrate the potential anticancer effects of these two agents on HNSCC cells by positively regulating apoptosis gene expression.

Indexed as

Antineoplastic AgentsHead and Neck NeoplasmsApoptosisCalixarenesCaspasesCell Line, TumorHumansQuaternary Ammonium CompoundsSquamous Cell Carcinoma of Head and NeckAntineoplastic AgentsCalixarenesCaspasespillar(5)areneQuaternary Ammonium CompoundsApoptosisCaspaseHead and neck squamous cell carcinomaPillar[5]arene

Identifiers

PMID37126106
PMCPMC11798307
OpenAlexW4367601667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.