ReviewApplied microbiology and biotechnology2023
Advances in the biosynthesis and metabolic engineering of rare ginsenosides.
Review in Applied microbiology and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol inSynthetic and systems biotechnology · 2026Article
- The Oplopanax elatus genome reveals dammaradienol synthase evolution enabling reconstruction of RK type ginsenosides biosynthesis.Nature communications · 2026Article
- Advances in Functional Genomics and Biotechnology for Enhancing Therapeutic Potential of Medicinal Plants.International journal of molecular sciences · 2026Review
- Recent Progress in the Regioselective Biotransformation and Multitarget Therapeutic Potential of Ginsenoside Rd.Molecules (Basel, Switzerland) · 2026Review
- Steam processing of Panax notoginseng with single-marker quantification: a green industrial standardization strategy.BMC chemistry · 2026Article
- Metabolic engineering of tobacco for heterologous production of rare ginsenosides CK and Rh2.Frontiers in plant science · 2026Article
- Protein design drives synthetic biology research of plant natural products.Biodesign research · 2025Review
- Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective.Microorganisms · 2025Review
- Methyl jasmonate induces the regulation of protostane triterpene biosynthesis by microRNAs in Alisma orientale.Protoplasma · 2025Article
- Introduction of human mMicrobial cell factories · 2025Article
- Biosynthesis and metabolic engineering of natural sweeteners.AMB Express · 2025Review
- Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3-O-UGT2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Overexpression of tRNA mFrontiers in microbiology · 2025Article
- Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges.Chinese herbal medicines · 2024Review
- Integrated Analysis of Ginsenoside Content and Biomarker Changes in Processed Ginseng: Implications for Anti-Cancer Mechanisms.Foods (Basel, Switzerland) · 2024Article
- Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco.Plant communications · 2024Article
- Transcriptomic Analysis Reveals the Flavonoid Biosynthesis Pathway Involved in Rhizome Development inPlants (Basel, Switzerland) · 2024Article
- Biotransformation of Ginsenoside Rb1 to Ginsenoside Rd and 7 Rare Ginsenosides UsingACS omega · 2024Article
- A terpenoids database with the chemical content as a novel agronomic trait.Database : the journal of biological databases and curation · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Rare ginsenosides are the deglycosylated secondary metabolic derivatives of major ginsenosides, and they are more readily absorbed into the bloodstream and function as active substances. The traditional preparation methods hindered the potential application of these effective components. The continuous elucidation of ginsenoside biosynthesis pathways has rendered the production of rare ginsenosides using synthetic biology techniques effective for their large-scale production. Previously, only the progress in the biosynthesis and biotechnological production of major ginsenosides was highlighted. In this review, we summarized the recent advances in the identification of key enzymes involved in the biosynthetic pathways of rare ginsenosides, especially the glycosyltransferases (GTs). Then the construction of microbial chassis for the production of rare ginsenosides, mainly in Saccharomyces cerevisiae, was presented. In the future, discovery of more GTs and improving their catalytic efficiencies are essential for the metabolic engineering of rare ginsenosides. This review will give more clues and be helpful for the characterization of the biosynthesis and metabolic engineering of rare ginsenosides. KEY POINTS: • The key enzymes involved in the biosynthetic pathways of rare ginsenosides are summarized. • The recent progress in metabolic engineering of rare ginsenosides is presented. • The discovery of glycosyltransferases is essential for the microbial production of rare ginsenosides in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.