Evidence map›Paper›PMID 37126069›Full record

ArticleThe Journal of urology2023

Diagnostic Performance and Safety of

Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Barry A Siegel, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin and 2 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04186845 (A Prospective, Phase 3, Multi Center, Single-arm, Imaging Study Investigating the Safety and Diagnostic Performance of rhPSMA 7.3), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04186845 phase3completednot on this map

A Prospective, Phase 3, Multi Center, Single-arm, Imaging Study Investigating the Safety and Diagnostic Performance of rhPSMA 7.3 (18F) PET Ligand in Men With Suspected Prostate Cancer Recurrence Based on Elevated PSA Following Prior Therapy (SPOTLIGHT)

TypeinterventionalSponsorBlue Earth DiagnosticsRan2020 to 2021Enrolled391ConditionsProstate CancerArmsrhPSMA-7.3 (18F) Injection, Positron emission tomography scan
3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. An intra-patient contemporaneous comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Trial
  2. Imaging Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  3. Imaging Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  4. Diuresis DuringJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  5. Interreader and Intrareader Reproducibility ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Trial
  6. True-PositiveJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Trial
  7. Review
  8. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  9. Value of a repeatEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  10. A Pilot Study ofThe Prostate · 2026
    Article
  11. Review
  12. Bladder activity of different PSMA PET radioligands and impact of furosemide.American journal of nuclear medicine and molecular imaging · 2026
    Article
  13. Challenges and Opportunities in Radioligand Therapy.Journal of nuclear medicine technology · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Utility ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ashesh B JaniDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Gregory C RavizziniDepartment of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Benjamin A GartrellDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Barry A SiegelDivision of Nuclear Medicine, Mallinckrodt Institute of Radiology and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri.
Przemyslaw TwardowskiDepartment of Genitourinary Oncology, John Wayne Cancer Institute, Santa Monica, California.
Daniel SaltzsteinUrology San Antonio, San Antonio, Texas.
Mark T FlemingVirginia Oncology Associates, US Oncology Research, Norfolk, Virginia.
Albert ChauBlue Earth Diagnostics Ltd, Oxford, United Kingdom.
Phillip DavisBlue Earth Diagnostics Inc, Monroe Township, New Jersey.
Brian F ChapinDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
David M SchusterDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
SPOTLIGHT Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSPOTLIGHT (NCT04186845) evaluated diagnostic performance and safety of radiohybrid MATERIALS AND

methodsMen with prostate cancer recurrence underwent positron emission tomography/CT 50-70 minutes after intravenous administration of 296±20% MBq

resultsThe overall

conclusions

Indexed as

Positron Emission Tomography Computed TomographyProstatic NeoplasmsHumansMaleNeoplasm Recurrence, LocalPositron-Emission TomographyProspective Studiesmolecular imagingpositron-emission tomographyprostatic neoplasms

Identifiers

PMID37126069
PMCPMC12721651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.