ReviewJournal of psychopathology and clinical science2023
The role of stress phenotypes in understanding childhood adversity as a transdiagnostic risk factor for psychopathology.
Review in Journal of psychopathology and clinical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Perceived Stress in Adolescence: Structure, Stability, and Its Relationship with Mental Health.European journal of investigation in health, psychology and education · 2026Article
- Decoding the cellular landscape of biological stress in the human brain.Neurobiology of stress · 2026Article
- Exploring intergenerational risk factors and mediators for child abuse potential in high-risk parents of young children.Frontiers in pediatrics · 2026Article
- Hair stress hormones in individuals with a recent suicide attempt experiencing a depressive episode.Neurobiology of stress · 2026Article
- Review
- Integration of positive environmental factors and differentiation of parental figures in social exposome research.Frontiers in psychology · 2025Article
- Stress reactivity moderates the association between early experiences of unpredictability and emotional problems in adolescents.Neurobiology of stress · 2025Article
- Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.Translational psychiatry · 2024Article
- Beyond abuse and neglect: validation of the childhood interpersonal trauma inventory in a community sample of adults.Frontiers in psychiatry · 2024Article
- Behavioural profiling following acute stress uncovers associations with future stress sensitivity and past childhood abuse.European journal of psychotraumatology · 2024Article
- A review of mental health disparities during COVID-19: Evidence, mechanisms, and policy recommendations for promoting societal resilience.Development and psychopathology · 2023Review
- Neural Sensitivity following Stress Predicts Anhedonia Symptoms: A 2-Year Multi-wave, Longitudinal Study.Research square · 2023Article
- Introduction to the Special Section: Developmental Perspectives on Trauma Exposure and Posttraumatic Stress.Journal of child & adolescent trauma · 2023Article
- Theories of psychopathology: Introduction to a special section.Journal of psychopathology and clinical science · 2023Article
- Psychobiological foundations of coping and emotion regulation: Links to maltreatment and depression in a racially diverse, economically disadvantaged sample of adolescent girls.Psychoneuroendocrinology · 2022Article
- The impact of social disadvantage on autonomic physiology of latinx adolescents: The role of environmental risks.New directions for child and adolescent development · 2022Article
- Exploring joint HPA-inflammatory stress response profiles in adolescent girls: Implications for developmental models of neuroendocrine dysregulation.Developmental psychobiology · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Childhood adversity is a leading transdiagnostic risk factor for psychopathology, being associated with an estimated 31-62% of childhood-onset disorders and 23-42% of adult-onset disorders (Kessler et al., 2010). Major unresolved theoretical challenges stem from the nonspecific and probabilistic nature of the links between childhood adversity and psychopathology. The links are nonspecific because childhood adversity increases risk, through a range of mechanisms, for diverse forms of psychopathology and are probabilistic because not all individuals exposed to childhood adversity develop psychopathology. In this article, we propose a path forward by focusing on stress phenotypes, defined as biobehavioral patterns activated in response to stressors that can disrupt future functioning when persistent (e.g., reward seeking, social withdrawal, aggression). This review centers on the accumulating evidence that psychopathology appears to be more strongly predicted by behavior and biology during states of stress. Building on this observation, our theoretical framework proposes that we can model pathways from childhood adversity to psychopathology with greater specificity and certainty by understanding stress phenotypes, defined as patterns of behavior and their corresponding biological substrates that are elicited by stressors. This approach aims to advance our conceptualization of mediating pathways from childhood adversity to psychopathology. Understanding stress phenotypes will bring us closer to "precision mental health," a person-centered approach to identifying, preventing, and treating psychopathology. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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