Evidence map›Paper›PMID 37125972›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2025

Pudendal Nerve Block by Adaptively Stepwise Increasing the Intensity of High-Frequency (10 kHz) Biphasic Stimulation.

Jianan Jian, Jicheng Wang, Bing Shen, Zhijun Shen, Khari Goosby, Joseph Scolieri, Jonathan Beckel, William C de Groat, Changfeng Tai

Open access · greenAbstract read
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jianan JianDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Jicheng WangDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Bing ShenDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Zhijun ShenDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Khari GoosbyDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Joseph ScolieriDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Jonathan BeckelDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
William C de GroatDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Changfeng TaiDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: cftai@pitt.edu.
University of Pittsburgh · US

Funding

Mechanism underlying Nerve Conduction Block by High Frequency (kHz) Biphasic StimulationR01NS109198 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAI, CHANGFENG · 2019 to 2022
$939k
NINDS NIH HHS R01 NS109198
6 · The paper itself

Abstract

objectiveThe purpose of this study is to determine whether adaptively stepwise increasing the intensity of a high-frequency (10 kHz) biphasic stimulation (HFBS) can produce nerve conduction block without generating a large initial response. MATERIALS AND

methodsIn anesthetized cats, three cuff electrodes were implanted on the left pudendal nerve for stimulation or block. The urethral pressure increase induced by pudendal nerve stimulation was used to measure the pudendal nerve block induced by HFBS.

resultsHFBS applied suddenly with a large step increase in intensity induced a large (86 ± 16 cmH

conclusionThis study is important for better understanding the possible mechanisms underlying the HFBS-induced nerve block and provides the possibility of developing a new nerve block method for clinical applications in which an initial large response is a concern.

Indexed as

Electric StimulationNerve BlockNeural ConductionPudendal NerveAnimalsCatsMaleUrethraBlockcathigh frequencynervestimulation

Identifiers

PMID37125972
PMCPMC10613126
OpenAlexW4367396711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.