Evidence map›Paper›PMID 37125620›Full record

ArticleMagnetic resonance in medicine2023

Identification of new resonances in downfield

Ravi Prakash Reddy Nanga, Mark A Elliott, Anshuman Swain, Neil E Wilson, Sophia Swago, Walter R Witschey, Ravinder Reddy

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Optimization ofMagnetic resonance in medicine · 2025
    Article
  4. Article
  5. Optimization ofmedRxiv : the preprint server for health sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ravi Prakash Reddy NangaCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3644-5656
Mark A ElliottCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anshuman SwainDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Neil E WilsonCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sophia SwagoDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8334-4746
Walter R WitscheyCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1669-2120
Ravinder ReddyCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · US

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
In vivo Mapping of Muscle Specific MetabolismR01AG071725 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2022 to 2026
$3.1M
Imaging of glutamatergic system changes in Alzheimer's disease in vivoR01AG063869 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2020 to 2024
$3.0M
Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarctionR01HL137984 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2018 to 2022
$2.8M
CrCEST MRI of Skeletal Muscle MetabolismR56AG062665 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2019 to 2019
$656k
NHLBI NIH HHS R01 HL137984NIA NIH HHS R01 AG063869NIA NIH HHS R01 AG071725NIA NIH HHS R56 AG062665NIBIB NIH HHS P41 EB029460
6 · The paper itself

Abstract

purposeThe purpose of this study was to identify and characterize newly discovered resonances appearing in the downfield proton MR spectrum (DF

methodsDownfield

resultsIn all participants, we observed new resonances at 9.7, 10.1, 10.3, and 10.9 ppm in the DF

conclusionWe have identified new proton resonances in vivo in human calf muscle occurring at chemical shifts of 9.7, 10.1, 10.3, and 10.9 ppm. These preliminary results are promising for investigating the role of NR/NMN and L-tryptophan metabolism in understanding the de novo and salvage pathways of NAD

Indexed as

NADProtonsHumansMuscle, SkeletalTryptophanWaterNADProtonsTryptophanWatercalf muscleDF 1H MRSdownfield proton spectroscopyNAD+nicotinamide adenosine dinucleotidenicotinamide mononucleotidenicotinamide ribosideproton magnetic resonance spectroscopyskeletal musclespectral excitationtryptophan

Identifiers

PMID37125620
PMCPMC10330283
OpenAlexW4367600433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.