Evidence map›Paper›PMID 37125546›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Specialist Availability and Drug Adherence in Older Adults with Dementia Across Regions of the United States.

Giovanna Pilonieta, Maria Pisu, Roy C Martin, Liang Shan, Richard E Kennedy, Gabriela Oates, Young-Il Kim, David S Geldmacher

Open access · greenAbstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. 4,4'-methylenediphenol reduces Aβ-induced toxicity in aFrontiers in aging neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giovanna PilonietaDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Maria PisuDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Roy C MartinDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Liang ShanSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Richard E KennedyAlzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Gabriela OatesDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Young-Il KimDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David S GeldmacherDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

RESEARCH TRAINING COREP60MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N. · 2003 to 2016
$16.2M
Project 2: Leveraging Ongoing Home Visitation Programs to Address Obesity Disparities among Underserved, Low-Income Mothers and ChildrenU54MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., GARVEY, W TIMOTHY · 2017 to 2022
$11.8M
UAB Alzheimer's Disease Research CenterP20AG068024 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROBERSON, ERIK D · 2020 to 2022
$3.3M
NIA NIH HHS P20 AG068024NIMHD NIH HHS P60 MD000502NIMHD NIH HHS U54 MD000502
6 · The paper itself

Abstract

backgroundAccess to specialists facilitates appropriate Alzheimer's disease and related dementia (ADRD) medication use and adherence. However, there is little information on the impact of specialists' availability on ADRD medication adherence, especially in regions of the United States (US) where specialists are scarce, e.g., the Deep South (DS).

objectiveTo ascertain whether the availability of specialty physicians in the DS and other US regions predicts ADRD medication adherence among community-dwelling older adultsMethods:We conducted secondary analyses of claims data for 54,194 Medicare beneficiaries with ADRD in 2013-2015. Medication adherence was measured using the proportion of days covered (PDC). Multivariable-adjusted Modified Poisson regression was used to examine associations of adherence with physicians' availability by region.

resultsThe race/ethnicity distribution was 81.44% white, 9.17% black, 6.24% Hispanic, 2.25% Asian, and 1% other; 71.81% were female, and 42.36% were older than 85 years. Beneficiaries across regions differed in all individual and contextual characteristics except sex and comorbidities. Neurologists and psychiatrists' availability was not significantly associated with adherence (DS = 1.00, 0.97-1.03 & non-DS = 1.01, 1.00-1.01). Race and having ≥1 specialist visits were associated with a lower risk of adherence in both regions (p < 0.0001). Advanced age, dual Medicare/Medicaid eligibility, and living in non-large metropolitan areas, were associated with adherence in the non-DS region.

conclusionAmong older Americans with ADRD, a context defined by specialist availability does not affect adherence, but other context characteristics related to socioeconomic status may. Research should further examine the influence of individual and contextual factors on ADRD treatment among older adults.

Indexed as

Alzheimer DiseaseMedicareAgedComorbidityFemaleHumansIndependent LivingMaleMedication AdherenceUnited StatesAlzheimer’s diseaseMedicaremedication adherencephysician availabilitysocioeconomic factorsspecialist use

Identifiers

PMID37125546
PMCPMC10634245
OpenAlexW4367310441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.