Evidence map›Paper›PMID 37125480›Full record

ArticlePediatrics2023

Characteristics Associated With Serious Self-Harm Events in Children and Adolescents.

Mert Sekmen, Carlos G Grijalva, Yuwei Zhu, Derek J Williams, James A Feinstein, Justine C Stassun, Jakobi A Johnson, Yasas C Tanguturi, James C Gay, James W Antoon

Abstract read
In one paragraph

Article in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Current Phenomenon of Self-Harm in Children and Adolescents.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mert SekmenDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt.
Carlos G GrijalvaHealth Policy.
Yuwei ZhuBiostatistics.
Derek J WilliamsDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt.
James A FeinsteinAdult and Child Center for Health Outcomes Research and Delivery Science, Children's Hospital Colorado, Aurora, Colorado.
Justine C StassunDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt.
Jakobi A JohnsonDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt.
Yasas C TanguturiDivision of Child & Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
James C GayDivision of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
James W AntoonDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt.

Funding

Risk Stratification and Decision Support to Improve Care and Outcomes in Children with PneumoniaR01AI125642 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILLIAMS, DEREK J. · 2017 to 2021
$3.3M
Vanderbilt Scholars in T4 Translational Research (V-STTaR) ProgramK12HL137943 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL, ROUMIE, CHRISTIANNE L. · 2017 to 2021
$2.9M
Mentoring in transmission of influenza and strategies for preventionK24AI148459 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2020 to 2024
$893k
Enhancing Medication Safety in Children with Polypharmacy Using Parent-Reported Symptom AssessmentsK23HD091295 · NICHD · UNIVERSITY OF COLORADO DENVER · PI FEINSTEIN, JAMES A · 2017 to 2021
$826k
Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in ChildrenK23AI168496 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ANTOON, JAMES W · 2022 to 2025
$740k
NHLBI NIH HHS K12 HL137943NIAID NIH HHS K23 AI168496NIAID NIH HHS K24 AI148459NIAID NIH HHS R01 AI125642NICHD NIH HHS K23 HD091295
6 · The paper itself

Abstract

objectivesTo identify patterns of psychiatric comorbidity among children and adolescents with a serious self-harm event.

methodsWe studied children aged 5 to 18 years hospitalized with a neuropsychiatric event at 2 children's hospitals from April 2016 to March 2020. We used Bayesian profile regression to identify distinct clinical profiles of risk for self-harm events from 32 covariates: age, sex, and 30 mental health diagnostic groups. Odds ratios (ORs) and 95% credible intervals (CIs) were calculated compared with a reference profile with the overall baseline risk of the cohort.

resultsWe included 1098 children hospitalized with a neuropsychiatric event (median age 14 years [interquartile range (IQR) 11-16]). Of these, 406 (37%) were diagnosed with a self-harm event. We identified 4 distinct profiles with varying risk for a self-harm diagnosis. The low-risk profile (median 0.035 [IQR 0.029-0.041]; OR 0.08, 95% CI 0.04-0.15) was composed primarily of children aged 5 to 9 years without a previous psychiatric diagnosis. The moderate-risk profile (median 0.30 [IQR 0.27-0.33]; reference profile) included psychiatric diagnoses without depressive disorders. Older female adolescents with a combination of anxiety, depression, substance, and trauma disorders characterized the high-risk profile (median 0.69 [IQR 0.67-0.70]; OR 5.09, 95% CI 3.11-8.38). Younger males with mood and developmental disorders represented the very high-risk profile (median 0.76 [IQR 0.73-0.79]; OR 7.21, 95% CI 3.69-15.20).

conclusionsWe describe 4 separate profiles of psychiatric comorbidity that can help identify children at elevated risk for a self-harm event and subsequent opportunities for intervention.

Indexed as

Self-Injurious BehaviorAdolescentAnxietyAnxiety DisordersBayes TheoremChildComorbidityFemaleHumansMale

Identifiers

PMID37125480
PMCPMC10233735

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.