Evidence map›Paper›PMID 37124644›Full record

ArticleRadiology. Cardiothoracic imaging2023

Cardiac MRI-derived Extracellular Volume Fraction versus Myocardium-to-Lumen R1 Ratio at Postcontrast T1 Mapping for Detecting Cardiac Amyloidosis.

Masafumi Kidoh, Seitaro Oda, Seiji Takashio, Yawara Kawano, Hidetaka Hayashi, Kosuke Morita, Takafumi Emoto, Shinsuke Shigematsu, Fumihiro Yoshimura, Takeshi Nakaura and 5 more

Abstract read
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Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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  4. Impactful Cardiac CT and MRI Articles from 2023.Radiology. Cardiothoracic imaging · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masafumi KidohDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-9589-7054
Seitaro OdaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID https://orcid.org/0000-0003-4101-5113
Seiji TakashioDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-6201-0701
Yawara KawanoDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-8269-440X
Hidetaka HayashiDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-8082-2842
Kosuke MoritaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-0163-5564
Takafumi EmotoDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-3258-4085
Shinsuke ShigematsuDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0001-6753-6473
Fumihiro YoshimuraDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0001-9277-2988
Takeshi NakauraDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-9010-0341
Yasunori NagayamaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0003-3280-7346
Masao MatsuokaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-0473-754X
Mitsuharu UedaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-6814-0582
Kenichi TsujitaDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0002-4314-259X
Toshinori HiraiDepartment of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).ORCID 0000-0003-1480-2197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the diagnostic performance of myocardium-to-lumen R1 (1/T1) ratio on postcontrast T1 maps for the detection of cardiac amyloidosis in a large patient sample. Materials and Methods: This retrospective study included consecutive patients who underwent MRI-derived extracellular volume fraction (MRI ECV) analysis between March 2017 and July 2021 because of known or suspected heart failure or cardiomyopathy. Pre- and postcontrast T1 maps were generated using the modified Look-Locker inversion recovery sequence. Diagnostic performances of MRI ECV and myocardium-to-lumen R1 ratio on postcontrast T1 maps (a simplified index not requiring a native T1 map and hematocrit level data) for detecting cardiac amyloidosis were evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. Results: Of 352 patients (mean age, 63 years ± 16 [SD]; 235 men), 136 had cardiac amyloidosis. MRI ECV showed 89.0% (121 of 136; 95% CI: 82%, 94%) sensitivity and 98.6% (213 of 216; 95% CI: 96%, 100%) specificity for helping detect cardiac amyloidosis (cutoff value of 40% [AUC, 0.99 {95% CI: 0.97, 1.00}; Conclusion: Postcontrast myocardium-to-lumen R1 ratio showed excellent diagnostic performance comparable to that of MRI ECV in the detection of cardiac amyloidosis.

Indexed as

CardiacCardiomyopathiesHeartMR Imaging

Identifiers

PMID37124644
PMCPMC10141336

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