Evidence map›Paper›PMID 37124638›Full record

ArticleRadiology. Cardiothoracic imaging2023

Artificial Intelligence Tool for Detection and Worklist Prioritization Reduces Time to Diagnosis of Incidental Pulmonary Embolism at CT.

Laurens Topff, Erik R Ranschaert, Annemarieke Bartels-Rutten, Adina Negoita, Renee Menezes, Regina G H Beets-Tan, Jacob J Visser

Open access · greenAbstract read
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Laurens TopffDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).ORCID https://orcid.org/0000-0003-1186-3007
Erik R RanschaertDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).ORCID https://orcid.org/0000-0001-9375-9750
Annemarieke Bartels-RuttenDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).ORCID https://orcid.org/0000-0001-6826-6065
Adina NegoitaDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).
Renee MenezesDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).ORCID https://orcid.org/0000-0002-1378-2721
Regina G H Beets-TanDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).
Jacob J VisserDepartment of Radiology (L.T., A.B.R., R.G.H.B.T.) and Department of Psychosocial Research and Epidemiology (R.M.), The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (L.T., R.G.H.B.T.); Department of Radiology, St Nikolaus Hospital, Eupen, Belgium (E.R.R.); Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (E.R.R.); Department of Radiology, La Moraleja Hospital, Madrid, Spain (A.N.); and Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands (J.J.V.).ORCID https://orcid.org/0000-0001-9935-2097
The Netherlands Cancer Institute · NLErasmus MC · NLGhent University · BEMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the diagnostic efficacy of artificial intelligence (AI) software in detecting incidental pulmonary embolism (IPE) at CT and shorten the time to diagnosis with use of radiologist reading worklist prioritization. Materials and Methods: In this study with historical controls and prospective evaluation, regulatory-cleared AI software was evaluated to prioritize IPE on routine chest CT scans with intravenous contrast agent in adult oncology patients. Diagnostic accuracy metrics were calculated, and temporal end points, including detection and notification times (DNTs), were assessed during three time periods (April 2019 to September 2020): routine workflow without AI, human triage without AI, and worklist prioritization with AI. Results: In total, 11 736 CT scans in 6447 oncology patients (mean age, 63 years ± 12 [SD]; 3367 men) were included. Prevalence of IPE was 1.3% (51 of 3837 scans), 1.4% (54 of 3920 scans), and 1.0% (38 of 3979 scans) for the respective time periods. The AI software detected 131 true-positive, 12 false-negative, 31 false-positive, and 11 559 true-negative results, achieving 91.6% sensitivity, 99.7% specificity, 99.9% negative predictive value, and 80.9% positive predictive value. During prospective evaluation, AI-based worklist prioritization reduced the median DNT for IPE-positive examinations to 87 minutes (vs routine workflow of 7714 minutes and human triage of 4973 minutes). Radiologists' missed rate of IPE was significantly reduced from 44.8% (47 of 105 scans) without AI to 2.6% (one of 38 scans) when assisted by the AI tool ( Conclusion: AI-assisted workflow prioritization of IPE on routine CT scans in oncology patients showed high diagnostic accuracy and significantly shortened the time to diagnosis in a setting with a backlog of examinations.

Indexed as

Computer ApplicationsCTDetectionDiagnosisEmbolismThoraxThrombosis

Identifiers

PMID37124638
PMCPMC10141443
OpenAlexW4366599061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.