Evidence map›Paper›PMID 37124533›Full record

ArticleFrontiers in oncology2023

Efficacy and safety of combined immunotherapy and stereotactic radiosurgery in NSCLCBM patients and a novel prognostic nomogram: A real-world study.

Shoaib Bashir, Lei Wen, Ping Zhang, Minting Ye, Yin Li, Weiping Hong, Junjie Zhen, Mingyao Lai, Hui Wang, Yanying Yang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Shoaib BashirOncology Department, First Affiliated Hospital of Jinan University, Guangzhou, China.
Lei WenOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Ping ZhangOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Minting YeOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Yin LiOncology Department, First Affiliated Hospital of Jinan University, Guangzhou, China.
Weiping HongOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Junjie ZhenOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Mingyao LaiOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Hui WangOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Yanying YangOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Xingrui ChenOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Rishun LuoOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Guoxia JiaOncology Department, First Affiliated Hospital of Jinan University, Guangzhou, China.
Yao GuoOncology Department, First Affiliated Hospital of Jinan University, Guangzhou, China.
Linbo CaiOncology Department, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Meng XuOncology Department, First Affiliated Hospital of Jinan University, Guangzhou, China.
Guangdong 999 Brain Hospital · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the effectiveness of combined immunotherapy (IT) and stereotactic radiosurgery (SRS) and address the gap between evidence-based clinical practice and academic knowledge of optimal timing of IT relative to SRS. In addition, to meet the unmet need for an up-to-date prognostic assessment model in the era of IT. Methods: The data of 86 non-small cell lung cancer brain metastasis (NSCLCBM) patients treated with SRS to 268 brain metastases (BMs) were retrospectively extracted from our hospital database. The Kaplan-Meier analysis was employed for overall survival (OS) and a log-rank test for comparison between groups. Cox proportional hazards regression models were used to identify the significant prognostic factors. The prognostic nomogram was established utilizing the rms package of R software. Results: IT was found to be associated with improved OS (from BM diagnosis: HR 0.363, 95% CI 0.199 - 0.661, Conclusion: Peri-SRS IT is a promising approach in treating NSCLCBM, as improved OS was observed without significantly increasing adverse events. Receipt of IT post-SRS was associated with superior OS than those who received IT concurrently or before. Incorporating IT and CITV into the RPA index could augment its prognosis assessment value for SRS-treated NSCLCBM patients, predominantly in the wild-type.

Indexed as

brain metastasesimmunotherapynon-small cell lung cancerprognostic nomogramstereotactic radiosurgery

Identifiers

PMID37124533
PMCPMC10141675
OpenAlexW4365511543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.