ArticleNeurology. Clinical practice2023
Stroke in Patients With Common Noncancerous Gynecologic Diseases: A Multicenter Study in Japan.
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Article in Neurology. Clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed, 8 citations in OpenAlex.
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22 authors at 1 institution in 1 country.
Kazuo YamashiroDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Takeo SatoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Chikako NitoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Yuji UenoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0002-8617-3695
Hiroyuki KawanoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Tetsuya ChibaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Takahito NishihiraDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Takafumi MizunoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Kentaro IshizukaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Yasuyuki IguchiDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Kazumi KimuraDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Kazuo KitagawaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Masatoshi KogaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0002-6758-4026
Teruyuki HiranoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Tomoaki KamedaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Hidehiro TakekawaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Takao UrabeDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Akiyo TaneichiDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Hiroyuki FujiwaraDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Shigeru FujimotoDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Nobutaka HattoriDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Ryota TanakaDepartment of Neurology (KY, YU, NH, RT), Juntendo University School of Medicine, Tokyo; Department of Neurology (KY, TU), Juntendo University Urayasu Hospital, Chiba; Department of Neurology (TS, YI), Jikei University School of Medicine, Tokyo; Department of Neurology (CN, Kazumi Kimura), Nippon Medical School, Tokyo; Department of Neurology (YU), University of Yamanashi; Department of Stroke and Cerebrovascular Medicine (HK, TH), Kyorin University, Tokyo; Department of Cerebrovascular Medicine (TC, MK), National Cerebral and Cardiovascular Center, Suita; Stroke Center (TN, HT), Dokkyo Medical University, Tochigi; Department of Neurology (TM, KI, Kazuo Kitagawa), Tokyo Women's Medical University, Tokyo; Department of Neurology (TK), Shin-Oyama City Hospital, Tochigi; Department of Obstetrics and Gynaecology (AT, HF), Jichi Medical University, Tochigi; and Division of Neurology (SF, RT), Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0003-3158-1955
Juntendo University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Gynecologic diseases such as uterine fibroids, endometriosis, and adenomyosis are common in women of reproductive age. Case reports and small case series have reported ischemic stroke in women with such common noncancerous gynecologic diseases, and their cause of stroke is frequently attributed to cryptogenic stroke or unconventional mechanisms related to hypercoagulability. However, stroke etiology and prognosis are not well known. We assessed the prevalence of and stroke mechanisms related to common noncancerous gynecologic diseases using hospital-based clinical data. Methods: We retrospectively identified consecutive female patients with common noncancerous gynecologic diseases (uterine fibroids, endometriosis, and adenomyosis) diagnosed with ischemic stroke/transient ischemic attack (TIA) between the ages of 20 and 59 years admitted to 10 stroke centers in Japan by reviewing prospectively collected data between 2017 and 2019. The clinical, laboratory, and neuroimaging features were evaluated and compared between patients with conventional stroke mechanisms (CSMs) (large artery atherosclerosis, small vessel occlusion, cardioembolism, and other determined etiology) and non-CSMs (cryptogenic stroke and causes related to hypercoagulability such as nonbacterial thrombotic endocarditis and paradoxical embolism) according to the Trial of Org 10172 in Acute Stroke Treatment criteria. Results: Of the 470 female patients with ischemic stroke/TIA, 39 (8%) (37 ischemic stroke and 2 TIA) had common noncancerous gynecologic diseases. The most common gynecologic diseases were uterine fibroids in 24 (62%) patients, followed by endometriosis in 9 (23%) and adenomyosis in 6 (15%). Twenty patients (51%) were assigned to the non-CSMs group, and 19 patients (49%) were assigned to the CSMs group. Adenomyosis and endometriosis were more frequent in the non-CSMs group than in the CSMs group. CA125 and D-dimer levels were higher in the non-CSMs group than in the CSMs group. Multiple vascular territory infarcts were frequent in patients with adenomyosis (60%) and endometriosis (43%) in the non-CSMs group. No stroke recurrence or death was observed within 3 months after discharge in both the CSMs and non-CSMs groups. Outcomes at 3 months after discharge were similar in both groups. Discussion: In patients with common noncancerous gynecologic diseases, hypercoagulopathy may play a role in the pathogenesis of ischemic stroke/TIA without CSMs.
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