ArticleBiological psychiatry global open science2023
Discrimination and Inflammation in Adolescents of Color.
Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.Biopsychosocial science and medicinePooled it
- The Effect of Yoga on Cancer-Related Fatigue and Quality of Life Among Racially and Ethnically Diverse Cancer Survivors: A Secondary Data Analysis.Journal of integrative and complementary medicine · 2025Trial
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Ancestry-linked IL-10 signaling and macrophage activation modulate fibroblast responses to oxidative stress in a PEG-based microphysiological system.npj biomedical innovations · 2026Article
- Perceived discrimination and monocyte abundance in older adults: Findings from the Health and Retirement Study.Psychoneuroendocrinology · 2025Article
- Disparities in Discrimination Distress Among U.S. Youth.AJPM focus · 2025Article
- The association of discrimination, inflammation, and coping style on self-rated health among South Asian individuals in the MASALA Study.Ethnicity & health · 2025Article
- Five hypothesized biological mechanisms linking adverse childhood experiences with anxiety, depression, and PTSD: A scoping review.Neuroscience and biobehavioral reviews · 2025Article
- Loneliness, Discrimination, Stress, and Type 2 Diabetes Risk in Young Adults.American journal of preventive medicine · 2025Article
- Manipulating immune activity of macrophages: a materials and mechanics perspective.Trends in biotechnology · 2025Review
- Racial Discrimination, Inflammation, Sleep, and Metabolic Syndrome From Adolescence to Young Adulthood.JAMA network open · 2024Article
- Racial Discrimination and Metabolic Syndrome in Young Black Adults.JAMA network open · 2024Article
- How Racial and Ethnic Discrimination Gets Under the Skin: Inflammatory Outcomes in Adolescents and Young Adults of Color.Biological psychiatry global open science · 2023Article
- From Discrimination to Disease: The Role of Inflammation.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: This study examined how experiences with discrimination relate to inflammation, a key biological pathway in mental and physical illnesses, and whether associations are moderated by gender across two samples of adolescents of color. Methods: Study 1 was a longitudinal study of 419 African American adolescents assessed on discrimination (ages 19-20), with trajectories of biomarkers of low-grade inflammation (C-reactive protein and soluble urokinase plasminogen activator receptor) measured from ages 25 to 29. Study 2 was a cross-sectional study of 201 eighth graders of color assessed on discrimination and mechanistic indicators of a proinflammatory phenotype: 1) in vitro studies of immune cells' inflammatory cytokine responses to stimuli; 2) in vitro studies of cells' sensitivity to anti-inflammatory agents; 3) circulating numbers of classical monocytes, key cellular drivers of low-grade inflammation; and 4) a composite of six biomarkers of low-grade inflammation. Results: Interactions of discrimination by gender were found across both studies. In study 1, African American males experiencing high discrimination showed increasing trajectories of soluble urokinase plasminogen activator receptor over time ( Conclusions: Discrimination is a pressing societal issue that will need to be addressed in efforts to promote health equity. This study suggests that adolescent males of color may be particularly vulnerable to its effects on mental health-relevant inflammatory processes.
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