ArticleBiological psychiatry global open science2023
Enhanced Immune Activation Following Acute Social Stress Among Adolescents With Early-Life Adversity.
Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 27 citations in OpenAlex.
- Stress-induced IL-6 response patterns amplify the link between daily negative affect and later depressive symptoms during bereavement.Brain, behavior, and immunity · 2026Article
- Differential associations between early life adversity subtypes and adolescent stress reactivity across neuroendocrine, autonomic, immune, and metabolic systems.Neurobiology of stress · 2026Article
- Sexual minority adults exhibit greater inflammation than heterosexual adults in the context of depressive symptoms and anxiety: Pathways to health disparities.Brain, behavior, and immunity · 2026Article
- Developmental origins of immune function: Maternal prenatal mood is associated with infant immune cell gene expression.Brain, behavior, and immunity · 2026Article
- Circulating cell-free mitochondrial DNA as a candidate marker of hyperinflammation and immune activation in pre-adolescents, adolescents and young adults with COVID-19 and comorbidities.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Stress-induced IL-6 regulation in pediatric bone growth disorders: current insights and therapeutic strategies.Frontiers in endocrinology · 2026Review
- Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats.Neurobiology of stress · 2026Article
- Sex, early life adversity, and negative self-evaluation shape the association between negative life events and depressive symptoms in adolescence.Scientific reports · 2025Article
- Neighborhood disadvantage and elevated CD14 gene expression among middle-aged adults: Findings from the Midlife in the United States study.Psychoneuroendocrinology · 2025Article
- Spousal bereavement enhances proinflammatory cytokine production to acute, psychological stress.Psychoneuroendocrinology · 2025Article
- Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents.Brain, behavior, and immunity · 2025Article
- Flourishing as resilience: Flourishing among Hispanic/Latino adolescents during the COVID-19 pandemic.Translational issues in psychological science · 2025Article
- Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study.Frontiers in psychiatry · 2025Article
- Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis.Frontiers in psychiatry · 2025Article
- Molecular connections between inflammation and social determinants of health.Frontiers in epidemiology · 2025Review
- Reward-seeking behaviors moderate the association between early life adversity and anhedonia 12 months later.Frontiers in behavioral neuroscience · 2025Article
- Neural and immune interactions linking early life stress and anhedonia.Brain, behavior, & immunity - health · 2024Article
- Leukocytes: Likely not the immune system's white knights in the wake of early life adversity.Brain, behavior, and immunity · 2024Article
- Early Life Stress and Major Depressive Disorder-An Update on Molecular Mechanisms and Synaptic Impairments.Molecular neurobiology · 2024Review
- DNA Methylation ofBiomolecules · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Background: Early-life adversity (ELA) has been linked to higher depression risk across the life span and chronic inflammatory conditions that contribute to earlier mortality. In this study, we characterized innate immune responses to acute social stress in a community sample of adolescents (mean age = 13.9 ± 1.6 years; 46.4% female) as a potential pathway linking ELA and depression pathogenesis. Methods: Parents reported their child's exposure to 9 ELAs, and adolescents participated in the Trier Social Stress Test for Children, with blood collected immediately before and then at 60 and 90 minutes thereafter. Overall, 65 adolescents had complete data for analysis of stress-induced changes in gene expression and 84 adolescents had complete data for circulating inflammatory markers. Results: Relative to adolescents exposed to no ELA (11.9%) or low ELA (ELA = 1-3; 67.9%), those exposed to high ELA (ELA = 4+; 20.2%) showed larger stress-associated increases in expression of both proinflammatory and innate antiviral gene transcripts in circulating blood. Consistent with a potential mediating role of sympathetic nervous system activity, promoter-based bioinformatics analyses implicated CREB transcription factor activity in structuring observed gene expression differences. These effects were accompanied by a smaller initial but protracted increase in circulating interleukin 6 in adolescents with high ELA. Conclusions: Results are consistent with the hypothesis that ELA may enhance cellular and gene regulatory reactivity to stress, which may, in turn, increase vulnerability to depression and other inflammation-related disease processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.