Evidence map›Paper›PMID 37124288›Full record

ArticleJACS Au2023

Differential Contributions of Distinct Free Radical Peroxidation Mechanisms to the Induction of Ferroptosis.

Quynh Do, Rutan Zhang, Gavin Hooper, Libin Xu

Open access · goldAbstract read
In one paragraph

Article in JACS Au, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Chemical Mechanisms of Lipid Peroxidation.Redox biochemistry and chemistry · 2025
    Article
  13. Review
  14. In defence of ferroptosis.Signal transduction and targeted therapy · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Ferroptosis and its role in gastric and colorectal cancers.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Quynh DoDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Rutan ZhangDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Gavin HooperDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Libin XuDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.ORCID https://orcid.org/0000-0003-1021-5200
University of Washington · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Oxysterols in SLOS Neurodevelopment: Pathological Role and TherapyR01HD092659 · NICHD · UNIVERSITY OF WASHINGTON · PI XU, LIBIN · 2017 to 2021
$1.9M
NICHD NIH HHS P50 HD103524NICHD NIH HHS R01 HD092659NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

Ferroptosis is a form of regulated cell death driven by lipid peroxidation of polyunsaturated fatty acids (PUFAs). Lipid peroxidation can propagate through either the hydrogen-atom transfer (HAT) or peroxyl radical addition (PRA) mechanism. However, the contribution of the PRA mechanism to the induction of ferroptosis has not been studied. In this study, we aim to elucidate the relationship between the reactivity and mechanisms of lipid peroxidation and ferroptosis induction. We found that while some peroxidation-reactive lipids, such as 7-dehydrocholesterol, vitamins D

Identifiers

PMID37124288
PMCPMC10131203
OpenAlexW4323051010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.