Evidence map›Paper›PMID 37124035›Full record

ReviewFrontiers in cellular and infection microbiology2023

Insights into oral microbiome and colorectal cancer - on the way of searching new perspectives.

Anna Kudra, Damian Muszyński, Bartosz Kamil Sobocki, Alessandro Atzeni, Ludovico Carbone, Karolina Kaźmierczak-Siedlecka, Karol Połom, Leszek Kalinowski

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna KudraScientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
Damian MuszyńskiScientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
Bartosz Kamil SobockiScientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.
Alessandro AtzeniInstitut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
Ludovico CarboneDepartment of Medicine Surgery and Neuroscience, University of Siena, Siena, Italy.
Karolina Kaźmierczak-SiedleckaDepartment of Medical Laboratory Diagnostics - Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland.
Karol PołomDepartment of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland.
Leszek KalinowskiDepartment of Medical Laboratory Diagnostics - Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist. Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated. It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes. The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as

Indexed as

Colorectal NeoplasmsMicrobiotaPeriodontal DiseasesFusobacterium nucleatumHumansPorphyromonas gingivalisVirulence FactorsVirulence Factorsbacterial virulence factorsbiofilmcolorectal canceroral microbiomeperiodontitis

Identifiers

PMID37124035
PMCPMC10130407

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.