Evidence map›Paper›PMID 37123972›Full record

ArticleHeliyon2023

Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts.

Zhenghua Zhang, Shasha Shen, Jiyao Ma, Tianfu Qi, Chao Gao, Xiong Hu, Dan Han, Yilong Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhenghua ZhangMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Shasha ShenMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Jiyao MaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Tianfu QiMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Chao GaoMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Xiong HuPathology Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Dan HanMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Yilong HuangMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
First Affiliated Hospital of Kunming Medical University · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the histological subtype and development of histologic features in the MPM xenograft model. Methods: MPM xenograft models were developed by injecting tumour cells into the right axillary space of nude mice. The T1, T2, R2*, T2*, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) at 14 d, 28 d, and 42 d were measured and compared between the epithelial and biphasic MPM. Correlations between multiparametric MRI parameters and histologic features, including necrotic fraction (NF) and microvessel density (MVD), were analysed. Results: This study found that T2, T2* and IVIM-DWI parameters can reflect the spatial and temporal heterogeneity of MPM. Compared to the epithelial MPM, T2 and T2* were higher and ADC, D, D*, and f were lower in the biphasic MPM ( Conclusion: MRI parameters changed with tumor progression in a xenograft model of MPM. MRI parameters may provide useful biomarkers for evaluating the histological subtype and histological features development of MPM.

Indexed as

Histological subtypeMalignant pleural mesotheliomaMicrovessel densityMultiparametric MRINecrosis

Identifiers

PMID37123972
PMCPMC10130770
OpenAlexW4364378751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.