Evidence map›Paper›PMID 37123439›Full record

ArticlePatterns (New York, N.Y.)2023

Toward structuring real-world data: Deep learning for extracting oncology information from clinical text with patient-level supervision.

Sam Preston, Mu Wei, Rajesh Rao, Robert Tinn, Naoto Usuyama, Michael Lucas, Yu Gu, Roshanthi Weerasinghe, Soohee Lee, Brian Piening and 5 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sam PrestonMicrosoft Research, Redmond, WA, USA.
Mu WeiMicrosoft Research, Redmond, WA, USA.
Rajesh RaoMicrosoft Research, Redmond, WA, USA.
Robert TinnMicrosoft Research, Redmond, WA, USA.
Naoto UsuyamaMicrosoft Research, Redmond, WA, USA.
Michael LucasMicrosoft Research, Redmond, WA, USA.
Yu GuMicrosoft Research, Redmond, WA, USA.
Roshanthi WeerasingheProvidence St Joseph's Health, Portland, OR, USA.
Soohee LeeProvidence St Joseph's Health, Portland, OR, USA.
Brian PieningProvidence Genomics & Earle A. Chiles Research Institute, Portland, OR, USA.
Paul TittelProvidence Genomics & Earle A. Chiles Research Institute, Portland, OR, USA.
Naveen ValluriMicrosoft Research, Redmond, WA, USA.
Tristan NaumannMicrosoft Research, Redmond, WA, USA.
Carlo BifulcoProvidence Genomics & Earle A. Chiles Research Institute, Portland, OR, USA.
Hoifung PoonMicrosoft Research, Redmond, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time consuming. Developing natural language processing (NLP) methods for structuring RWD is thus essential for scaling real-world evidence generation. We propose leveraging patient-level supervision from medical registries, which are often readily available and capture key patient information, for general RWD applications. We conduct an extensive study on 135,107 patients from the cancer registry of a large integrated delivery network (IDN) comprising healthcare systems in five western US states. Our deep-learning methods attain test area under the receiver operating characteristic curve (AUROC) values of 94%-99% for key tumor attributes and comparable performance on held-out data from separate health systems and states. Ablation results demonstrate the superiority of these advanced deep-learning methods. Error analysis shows that our NLP system sometimes even corrects errors in registrar labels.

Indexed as

data miningE01.789.625H02.403.429.515L01.224.050.375.580L01.313.500.750.280.199medical oncologynatural language processingneoplasm staging

Identifiers

PMID37123439
PMCPMC10140604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.