Evidence map›Paper›PMID 37123241›Full record

ArticleiScience2023

A biomarker of opioid-induced respiratory toxicity in experimental studies.

Marieke Hellinga, Marijke Hyke Algera, Rutger van der Schrier, Elise Sarton, Monique van Velzen, Albert Dahan, Erik Olofsen, Marieke Niesters

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marieke HellingaDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Marijke Hyke AlgeraDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Rutger van der SchrierDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Elise SartonDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Monique van VelzenDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Albert DahanDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Erik OlofsenDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Marieke NiestersDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioids are commonly used painkillers and drugs of abuse and have serious toxic effects including potentially lethal respiratory depression. It remains unknown which respiratory parameter is the most sensitive biomarker of opioid-induced respiratory depression (OIRD). To evaluate this issue, we studied 24 volunteers and measured resting ventilation, resting end-tidal PCO

Indexed as

Health sciencesPharmacologyToxicology

Identifiers

PMID37123241
PMCPMC10139987
OpenAlexW4361246535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.