ArticleArchives of Razi Institute2022
Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice.
Article in Archives of Razi Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Nacre extract attenuates age-related functional and tissue alterations under post-onset intervention conditions in two murine aging models.Biogerontology · 2026Article
- Non-targeted Metabolomics Reveals the Potential Role of MFSD8 in Metabolism in Human Endothelial Cells.Molecular biotechnology · 2026Article
- Multiple Exposures to Sevoflurane General Anesthesia During Pregnancy Inhibit CaMKII/CREB Axis by Downregulating HCN2 to Induce an Autism-Like Phenotype in Offspring Mice.Journal of molecular neuroscience : MN · 2024Article
- Oral Administration of Nacre Extract from Pearl Oyster Shells Has Anti-Aging Effects on Skin and Muscle, and Extends the Lifespan in SAMP8 Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-citrulline (L-cit) is a nonessential amino acid that interacts with the veracity of neurotransmitters in the brain and might have a positive effect on fetal growth. However, there is no information about the possible effect of L-cit on reflexive motor behavior. Thus, this study aimed to determine the effects of prenatal exposure to L-cit on reflexive motor behavior in mice offspring. Forty pregnant female mice were allocated into four groups. In the control group, mice received water, while in groups 2-4, female mice orally gavage with L-cit (25, 50, and 100 mg/kg) at 5, 8, 11, 14, and 17 days of gestation (GD). Following delivery, pups were selected, and reflexive motor behaviors were determined using ambulation, hind-limb foot angle, surface righting, hind-limb strength, grip strength, front limb suspension, and negative geotaxis tests. Also, serum Nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined. Based on the findings, maternal exposure to L-cit improved ambulation score, hind-limb suspension score, grip strength, and front-limb suspension in offspring (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.