ArticlePeerJ2023
CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability.
Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Age-related tumor mutational burden and inflammaging: a pan-cancer multi-omics study of treatment-naïve patients.Immuno-oncology technology · 2026Article
- Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion.Cancer medicine · 2026Article
- Multi-omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine.Molecular oncology · 2025Article
- In silico generation of synthetic cancer genomes using generative AI.Cell genomics · 2025Article
- Pan-cancer human brain metastases atlas at single-cell resolution.Cancer cell · 2025Article
- Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine.Biology direct · 2024Article
- Molecular profiling of a bladder cancer with very high tumour mutational burden.Cell death discovery · 2024Article
- Genetically driven predisposition leads to an unusually genomic unstable renal cell carcinoma.Discover oncology · 2024Article
- Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype.Discover oncology · 2024Article
- Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers.Cancer reports (Hoboken, N.J.) · 2023Article
- Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers.bioRxiv : the preprint server for biology · 2023Article
- Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis.eLife · 2023Article
- Identification of a Gene-Expression-Based Surrogate of Genomic Instability during Oral Carcinogenesis.Cancers · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological phenotypes associated with these diseases by measuring structural and numerical chromosomal alterations. There have been multiple chromosomal instability scores developed across many studies in the literature; however, these scores have not been compared because of the lack of a single tool available to calculate and facilitate these various metrics. Here, we provide an R package CINmetrics, that calculates six different chromosomal instability scores and allows direct comparison between them. We also demonstrate how these scores differ by applying CINmetrics to breast cancer data from The Cancer Genome Atlas (TCGA). The package is available on CRAN at https://cran.rproject.org/package=CINmetrics and on GitHub at https://github.com/lasseignelab/CINmetrics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.