Evidence map›Paper›PMID 37122902›Full record

ReviewBioactive materials2023

Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration.

Shang Lyu, Zhifei Dong, Xiaoxiao Xu, Ho-Pan Bei, Ho-Yin Yuen, Chung-Wai James Cheung, Man-Sang Wong, Yong He, Xin Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed.

  1. Trial
  2. Review
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  5. Article
  6. Article
  7. Therapeutic potential ofPharmaceutical biology · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. [Frontier research on smart delivery biomaterials in the field of oral tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Review

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shang LyuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Zhifei DongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Xiaoxiao XuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Ho-Pan BeiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Ho-Yin YuenDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Chung-Wai James CheungDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Man-Sang WongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.
Yong HeState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, PR China.
Xin ZhaoDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy.

Indexed as

Drug deliveryMicrofabricationMicroneedlesTissue regenerationWound healing

Identifiers

PMID37122902
PMCPMC10140753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.