Evidence map›Paper›PMID 37122754›Full record

ReviewFrontiers in immunology2023

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer.

Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  16. The role of Vps4 in cancer development.Frontiers in oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ding-Yu RaoDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
De-Fa HuangLaboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Mao-Yan SiThe First Clinical College, Gannan Medical University, Ganzhou, China.
Hua LuThe First Clinical College, Southern Medical University, Guangzhou, China.
Zhi-Xian TangDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Zu-Xiong ZhangDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
First Affiliated Hospital of Gannan Medical University · CNGannan Medical University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes are widely present in various body fluids, and therefore they can be used as a potential tool for non-invasive liquid biopsy. The present study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy as a first-line treatment for patients with NSCLC, this study also briefly describes the occurrence of EGRF+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.

Indexed as

Carcinoma, Non-Small-Cell LungExosomesLung NeoplasmsErbB ReceptorsHumansTumor MicroenvironmentEGFR protein, humanErbB ReceptorsEGFRepithelial to mesenchymal transformation (EMT)exosomelung cancertarget therapytumor microenvironment (TME)

Identifiers

PMID37122754
PMCPMC10130367
OpenAlexW4365148831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.