Evidence map›Paper›PMID 37122732›Full record

Observational studyFrontiers in immunology2023

Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study.

Geraldo Magela Fernandes, Lizandra Moura Paravidine Sasaki, Gabriela Profírio Jardim-Santos, Heidi Luise Schulte, Felipe Motta, Ângelo Pereira da Silva, Aleida Oliveira de Carvalho, Yacara Ribeiro Pereira, Caroline de Oliveira Alves, David Alves de Araújo Júnior and 29 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 6 institutions in 1 country.

Geraldo Magela FernandesPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Lizandra Moura Paravidine SasakiPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Gabriela Profírio Jardim-SantosPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Heidi Luise SchultePrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Felipe MottaPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Ângelo Pereira da SilvaHospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, Brazil.
Aleida Oliveira de CarvalhoHospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, Brazil.
Yacara Ribeiro PereiraHospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, Brazil.
Caroline de Oliveira AlvesFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
David Alves de Araújo JúniorHospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, Brazil.
Dayde Lane Mendonça-SilvaHospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, Brazil.
Karina Nascimento CostaFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
Maria Eduarda Canellas de CastroPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Lucas LauandFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
Rodrigo de Resende NeryFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
Rosana TristãoFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
Patricia Shu KurizkyPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Otávio de Toledo NóbregaPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Laila Salmen EspindolaPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Luiz Cláudio Gonçalves de CastroPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Patrícia Nessralla AlpoimFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Lara Carvalho GodoiFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luci Maria Sant Ana DusseFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jordana Grazziela Alves Coelho-Dos-ReisLaboratório de Virologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Laurence Rodrigues do AmaralLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, Patos de Minas, Brazil.
Matheus de Souza GomesLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, Patos de Minas, Brazil.
Pedro Luiz Lima BertariniLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, Patos de Minas, Brazil.
Joaquim Pedro Brito-de-SousaInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Ismael Artur da Costa-RochaInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Ana Carolina Campi-AzevedoInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Vanessa Peruhype-MagalhãesInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Andrea Teixeira-CarvalhoInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Alberto Moreno ZaconetaFaculdade de Medicina, Universidade de Brasília (UnB), Brasília, Brazil.
Alexandre Anderson de Sousa Munhoz SoaresPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Valéria ValimHospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo (HUCAM-UFES), Vitória, Brazil.
Ciro Martins GomesPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Cleandro Pires de AlbuquerquePrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Olindo Assis Martins-FilhoInstituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil.
Licia Maria Henrique da MotaPrograma de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília, Brazil.
Universidade de Brasília · BRFundação Oswaldo Cruz · BRHospital Universitário de Brasília · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de Uberlândia · BRUniversidade Federal do Espírito Santo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: SARS-CoV-2 infection during pregnancy can induce changes in the maternal immune response, with effects on pregnancy outcome and offspring. This is a cross-sectional observational study designed to characterize the immunological status of pregnant women with convalescent COVID-19 at distinct pregnancy trimesters. The study focused on providing a clear snapshot of the interplay among serum soluble mediators. Methods: A sample of 141 pregnant women from all prenatal periods (1 Results: In the HC group, most serum soluble mediators progressively decreased towards the 2 Discussion and conclusion: From an overall perspective, a pronounced increase in serum levels of soluble mediators with decreased network interplay between them demonstrated an imbalanced immune response in convalescent COVID-19 infection during pregnancy that may contribute to the management of, or indeed recovery from, late complications in the post-symptomatic phase of the SARS-CoV-2 infection in pregnant women.

Indexed as

COVID-19Pregnant PeopleChemokinesCross-Sectional StudiesCytokinesFemaleHumansInterleukin-17Interleukin-6PregnancyPregnancy OutcomeSARS-CoV-2ChemokinesCytokinesInterleukin-17Interleukin-6chemokinesCOVID-19cytokinesgrowth factorspregnancy

Identifiers

PMID37122732
PMCPMC10130456
OpenAlexW4365142581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.