Evidence map›Paper›PMID 37122711›Full record

ArticleFrontiers in immunology2023

Growth hormone secretagogues modulate inflammation and fibrosis in

Brigida Boccanegra, Ornella Cappellari, Paola Mantuano, Daniela Trisciuzzi, Antonietta Mele, Lisamaura Tulimiero, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Alessandro Giovanni Cerchiara and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Structure optimization and molecular dynamics studies of new tumor-selectiveJournal of enzyme inhibition and medicinal chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Brigida BoccanegraDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Ornella CappellariDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Paola MantuanoDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Daniela TrisciuzziDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Antonietta MeleDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Lisamaura TulimieroDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Michela De BellisDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Santa CirmiDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Francesca SanaricaDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Alessandro Giovanni CerchiaraDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Elena ConteDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Ramona MeantiSchool of Medicine and Surgery, University of Milan-BICOCCA, Milan, Italy.
Laura RizziSchool of Medicine and Surgery, University of Milan-BICOCCA, Milan, Italy.
Elena BrescianiSchool of Medicine and Surgery, University of Milan-BICOCCA, Milan, Italy.
Severine DenoyelleInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier-ENSCM, Faculté de Pharmacie, Montpellier, France.
Jean-Alain FehrentzInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier-ENSCM, Faculté de Pharmacie, Montpellier, France.
Gabriele CrucianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Orazio NicolottiDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Antonella LiantonioDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Antonio TorselloSchool of Medicine and Surgery, University of Milan-BICOCCA, Milan, Italy.
Annamaria De LucaDepartment of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
University of Bari Aldo Moro · ITUniversity of Milano-Bicocca · ITÉcole Nationale Supérieure de Chimie de Montpellier · FRInstitut des Biomolécules Max Mousseron · FRUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Growth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin-converting enzyme. These mechanisms are of interest for potentially targeting multiple steps of pathogenic cascade in Duchenne muscular dystrophy (DMD). Methods: Here, we aimed to provide preclinical evidence for potential benefits of GHSs in DMD, Results: Discussion: Our results support the interest of GHSs as modulators of pathology progression in

Indexed as

Growth HormoneInsulin-Like Growth Factor IMuscular Dystrophy, DuchenneSecretagoguesAnimalsDisease Models, AnimalFibrosisInflammationMaleMiceMice, Inbred mdxGrowth HormoneInsulin-Like Growth Factor ISecretagoguesDuchenne muscular dystrophyfibrosisgrowth hormone secretagoguesmdx mouseskeletal muscle

Identifiers

PMID37122711
PMCPMC10130389
OpenAlexW4365142625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.