Evidence map›Paper›PMID 37122422›Full record

ArticleSAGE open medical case reports2023

A convoluted path to the diagnosis of hepatocellular carcinoma in a resource-limited setting.

W C Sithole, S Pillay, B Mbanjwa, N Magula

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

W C SitholeDepartment of Internal Medicine, King Edward VIII Hospital and Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.ORCID https://orcid.org/0000-0001-6947-1482
S PillayDepartment of Internal Medicine, King Edward VIII Hospital and Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.ORCID https://orcid.org/0000-0002-5604-645X
B MbanjwaDepartment of Internal Medicine, King Edward VIII Hospital and Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.ORCID https://orcid.org/0000-0001-8102-6816
N MagulaDepartment of Internal Medicine, Clairwood Hospital and Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
King Edward VIII Hospital · ZAUniversity of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide, chronic hepatitis B virus infection remains the main aetiology of hepatocellular carcinoma, while human immunodeficiency virus may hasten the evolution of hepatocellular carcinoma in those co-infected with hepatitis B virus/human immunodeficiency virus. We describe a 29-year-old female with unmonitored hepatitis B virus infection for over 5 years, human immunodeficiency virus disease on a tenofovir-based antiretroviral regimen for 11 months, who presented with a 2-week history of epistaxis and abnormal vaginal bleeding, associated with unintentional weight loss of 4 months duration. After extensive investigation, a definitive diagnosis of hepatocellular carcinoma was established based on histopathological assessment in the presence of a positive hepatitis B envelope antigen, mildly raised alpha feto-protein, and a non-cirrhotic liver. Periodic surveillance for hepatocellular carcinoma in patients with chronic hepatitis B virus infection is important, particularly in those with evidence of actively replicating hepatitis B virus for early detection and implementation of curative therapies to reduce mortality and morbidity.

Indexed as

alpha feto-proteinantiretroviral therapyhepatitis B virus/human immunodeficiency virus co-infectionHepatocellular carcinomamonitoring of hepatitis B infection

Identifiers

PMID37122422
PMCPMC10134145
OpenAlexW4367020189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.