ArticleFrontiers in neurology2023
The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Multi-Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome-Wide Association Meta-Analyses, Machine Learning, and Drug Repurposing Study.Brain and behavior · 2026Pooled it
- Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Fremanezumab for the Treatment of Patients With Migraine and Comorbid Major Depressive Disorder: The UNITE Randomized Clinical Trial.JAMA neurology · 2025Trial
- Risk factors for major depressive disorder among adults recruited from hospital settings in Uganda, Kenya, Ethiopia and South Africa.Nature communications · 2026Article
- Psychiatric Disorders, Headache Comorbidity, and Quality of Life in a Psychiatric Outpatient Clinic.The Psychiatric quarterly · 2026Article
- Modifiable and clinically actionable exposures for vascular dementia: a structured evidence synthesis of Mendelian randomization studies.Journal of neurology · 2026Review
- Shared genetic architecture between depression and migraine: a large-scale genome-wide cross-trait analysis.The journal of headache and pain · 2026Article
- Evolution of use and overuse of triptans in Austria - What has changed in the last 15 years?The journal of headache and pain · 2026Article
- A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.Journal of pain research · 2026Article
- Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?Pediatric neurology · 2025Article
- Associations between temporomandibular disorders/bruxism and head and neck pains: a bidirectional Mendelian randomization study.Journal of oral & facial pain and headache · 2025Article
- Unraveling the link: exploring what risk factor for sleep disorders among paediatric migraine.BMC neurology · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Association between chronic pain and mental health among nurses in China: a national cross-sectional study.BMC nursing · 2025Article
- Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders.European journal of medical research · 2025Article
- Causal associations of inflammatory cytokines and urinary stones: a two-sample Mendelian randomization study.Translational andrology and urology · 2025Article
- A Hybrid Digital-4E Strategy for comorbid migraine and depression: a medical hypothesis on an AI-driven, neuroadaptive, and exposome-aware approach.Frontiers in neurology · 2025Article
- NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder.Frontiers in psychiatry · 2025Article
- Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Translational psychiatry · 2024Article
- A cause-effect relationship between uterine diseases and breast cancer: A bidirectional Mendelian randomization study.Heliyon · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous epidemiological and other studies have shown an association between major depressive disorder (MDD) and migraine. However, the causal relationship between them remains unclear. Therefore, this study aimed to investigate the causal relationship between MDD and migraine using a bidirectional, two-sample Mendelian randomization (MR) approach. Methods: Data on MDD and migraine, including subtypes with aura migraine (MA) and without aura migraine (MO), were gathered from a publicly available genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) utilized as instrumental variables (IVs) were then screened by adjusting the intensity of the connection and removing linkage disequilibrium. To explore causal effects, inverse variance weighting (IVW) was used as the primary analysis method, with weighted median, MR-Egger, simple mode, and weighted mode used as supplementary analytic methods. Furthermore, heterogeneity and pleiotropy tests were carried out. Cochran's Q-test with IVW and MR-Egger was used to assess heterogeneity. Pleiotropy testing was carried out using the MR-Egger intercept and MR-PRESSO analysis methods. A leave-one-out analysis was also used to evaluate the stability of the findings. Finally, we used migraine (MA and MO) levels to deduce reverse causality with MDD risk. Results: Random effects IVW results were (MDD-Migraine: odds ratio (OR), 1.606, 95% confidence interval (CI), 1.324-1.949, Conclusion: Our study confirms a causal relationship between MDD levels and increased risk of migraine, MA, and MO. There was little evidence in the reverse MR analysis to suggest a causal genetic relationship between migraine (MA and MO) and MDD risk levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.