Evidence map›Paper›PMID 37122224›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2023

Cardiomyocyte electrophysiology and its modulation: current views and future prospects.

Christopher L-H Huang, Ming Lei

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  8. Synergistic antiarrhythmic mechanism of IJournal of translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.ORCID 0000-0001-9553-6112
Ming LeiDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.ORCID 0000-0002-0928-341X

Funding

British Heart Foundation FS/PHD/20/29053British Heart Foundation PG/14/79/31102British Heart Foundation PG/15/12/31280British Heart Foundation PG/16/67/32340British Heart Foundation PG/21/10512Medical Research Council MR/M001288/1Wellcome Trust 105 727/Z/14/Z
6 · The paper itself

Abstract

Normal and abnormal cardiac rhythms are of key physiological and clinical interest. This introductory article begins from Sylvio Weidmann's key historic 1950s microelectrode measurements of cardiac electrophysiological activity and Singh & Vaughan Williams's classification of cardiotropic targets. It then proceeds to introduce the insights into cardiomyocyte function and its regulation that subsequently emerged and their therapeutic implications. We recapitulate the resulting view that surface membrane electrophysiological events underlying cardiac excitation and its initiation, conduction and recovery constitute the final common path for the cellular mechanisms that impinge upon this normal or abnormal cardiac electrophysiological activity. We then consider progress in the more recently characterized successive regulatory hierarchies involving Ca

Indexed as

Arrhythmias, CardiacMyocytes, CardiacElectrophysiological PhenomenaElectrophysiologyHumansSignal TransductionCa2+ homeostasiscardiac arrhythmiacardiac remodellingcardiac rhythmion channelsmetabolic oxidation

Identifiers

PMID37122224
PMCPMC10150219

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.