Evidence map›Paper›PMID 37122217›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2023

Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge.

Eunjeong Jung, Rebecca Capel, Congshan Jiang, Elisa Venturi, Georgiana Neagu, Sarah Pearcey, Yafei Zhou, Yanmin Zhang, Ming Lei

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  5. Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  6. Cardiomyocyte electrophysiology and its modulation: current views and future prospects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Eunjeong JungDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Rebecca CapelDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Congshan JiangNational Regional Children's Medical Center (Northwest); Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province; Xi'an Key Laboratory of Children's Health and Diseases, Shaanxi Institute for Pediatric Diseases; Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University. No. 69, Xijuyuan Lane, Xi'an 710003, People's Republic of China.
Elisa VenturiDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Georgiana NeaguDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Sarah PearceyPaediatric Intensive Care, Addenbrooke's Hospital, Cambridge CB2 1QY, UK.
Yafei ZhouNational Regional Children's Medical Center (Northwest); Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province; Xi'an Key Laboratory of Children's Health and Diseases, Shaanxi Institute for Pediatric Diseases; Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University. No. 69, Xijuyuan Lane, Xi'an 710003, People's Republic of China.
Yanmin ZhangNational Regional Children's Medical Center (Northwest); Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province; Xi'an Key Laboratory of Children's Health and Diseases, Shaanxi Institute for Pediatric Diseases; Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University. No. 69, Xijuyuan Lane, Xi'an 710003, People's Republic of China.ORCID 0000-0001-7580-4693
Ming LeiDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.ORCID 0000-0002-0928-341X
University of Oxford · GBChildren's National · USAddenbrooke's Hospital · GBSouthwest Medical University · CN

Funding

British Heart Foundation FS/PHD/20/29053British Heart Foundation PG/12/21/29473British Heart Foundation PG/14/80/31106British Heart Foundation PG/16/67/32340British Heart Foundation PG/21/10512Medical Research Council G10002647
6 · The paper itself

Abstract

P21-activated kinase 1 (Pak1) signalling plays a vital and overall protective role in the heart. However, the phenotypes of

Indexed as

Atrial FibrillationAdrenergic AgentsAnimalsCalciumMiceMice, KnockoutMyocytes, Cardiacp21-Activated KinasesRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerAdrenergic AgentsCalciump21-Activated KinasesRyanodine Receptor Calcium Release ChannelSlc8a2 protein, mouseSodium-Calcium Exchangeratrial arrhythmiaatrial fibrillationelectrophysiologyisoprenalinep21-activated kinase 1

Identifiers

PMID37122217
PMCPMC10150202
OpenAlexW4367600608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.