Evidence map›Paper›PMID 37122210›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2023

Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes.

Bin Zeng, Xiang Zhang, Rainer Schimpf, Andrew Powers, Michael Glikson, Charles Antzelevitch, Dan Hu, Hector Barajas-Martinez

Open access · greenAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Cardiomyocyte electrophysiology and its modulation: current views and future prospects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Bin ZengDepartment of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.
Xiang ZhangDepartment of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.ORCID 0000-0001-9494-6064
Rainer SchimpfCardiology Practice Clinic, Ludwig-Guttmann-Str. 11, Ludwigshafen, Ludwigshafen-Neustadt, 67071, Germany.
Andrew PowersDepartment of Biology, University at Albany, State University of New York, Albany, NY, 12222, USA.
Michael GliksonJesselson Integrated Heart Center, Shaare Zedek Medical Center and Hebrew University Faculty of Medicine, Jerusalem, 91031, Israel.
Charles AntzelevitchLankenau Institute for Medical Research, and Lankenau Heart Institute, Wynnwood, Pennsylvania, PA, 19096, USA.
Dan HuDepartment of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.ORCID 0000-0002-0994-8434
Hector Barajas-MartinezDepartment of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.
Wuhan University · CNThomas Jefferson University · USAlbany State University · USKlinikum Ludwigshafen · DEShaare Zedek Medical Center · IL

Funding

ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
Development of a whole heart model of the J wave syndromes and novel approaches to pharmacologic management of associated life-threatening arrhythmiasR01HL152201 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES, DI DIEGO, JOSE M. · 2020 to 2023
$2.5M
Novel Approaches to Pharmacologic Management of Life-Threatening Arrhythmias Associated with the J Wave SyndromesR56HL138103 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES · 2018 to 2018
$413k
NHLBI NIH HHS R01 HL047678NHLBI NIH HHS R01 HL152201NHLBI NIH HHS R56 HL138103
6 · The paper itself

Abstract

J wave syndrome (JWS) is an inherited cardiac channelopathy associated with malignant ventricular arrhythmias and sudden cardiac death (SCD), which comprises early repolarization syndrome and Brugada syndrome. Here, we explore the association between variants in the

Indexed as

Brugada SyndromeDeath, Sudden, CardiacBase SequenceCalcium Channels, L-TypeHumansMutationCalcium Channels, L-TypeBrugada syndromeearly repolarization syndromeelectrophysiologygeneticssudden cardiac death

Identifiers

PMID37122210
PMCPMC10150203
OpenAlexW4367600645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.