Evidence map›Paper›PMID 37122209›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2023

A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.

Paulina Langa, Sanam Shafaattalab, Paul H Goldspink, Beata M Wolska, Aurelia A Fernandes, Glen F Tibbits, R John Solaro

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Cardiomyocyte electrophysiology and its modulation: current views and future prospects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Paulina LangaDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA.ORCID 0000-0002-0334-1391
Sanam ShafaattalabMolecular Biology and Biochemistry; BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4; Simon Fraser University Burnaby, British Columbia, V5A 4H4, Canada.
Paul H GoldspinkDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA.
Beata M WolskaDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA.
Aurelia A FernandesDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA.
Glen F TibbitsMolecular Biology and Biochemistry; BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4; Simon Fraser University Burnaby, British Columbia, V5A 4H4, Canada.
R John SolaroDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA.
Simon Fraser University · CAUniversity of Illinois Chicago · US

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4M
Signaling To and From the Vascular/Endothelial Compartment and Progression of HCM Linked to Sarcomere MutationsR01HL158634 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDSPINK, PAUL H, SOLARO, R JOHN · 2022 to 2025
$3.1M
Myofilament signaling and cardiac disordersR01HL128468 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOLARO, R JOHN, WOLSKA, BEATA M. · 2016 to 2019
$1.6M
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL128468NHLBI NIH HHS R01 HL158634
6 · The paper itself

Abstract

In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding mutant proteins of the sarcomere. We recently reported an upregulation of elements in the Notch signalling cascade in cardiomyocytes derived from human inducible pluripotent stem cells expressing a TNNT2 variant encoding cardiac troponin T (cTnT-I79N

Indexed as

CardiomyopathiesCardiomyopathy, DilatedCardiomyopathy, HypertrophicHumansHypertrophyMutationTroponin TTroponin Tarrythmiasdilated cardiomyopathyHippo signallinghypertrophic cardiomyopathyNotch

Identifiers

PMID37122209
PMCPMC10150215
OpenAlexW4367600767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.