Evidence map›Paper›PMID 37122176›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.

Moataz A Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, Eslam B Elkaeed, Rofaida Salem, Claudiu T Supuran and 2 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Moataz A ShaldamDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.ORCID 0000-0002-0420-4364
Hadia AlmahliDepartment of Chemistry, University of Cambridge, Cambridge, UK.
Andrea AngeliDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0002-1470-7192
Rehab Mustafa BadiDepartment of Medical Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Eman F KhaleelDepartment of Medical Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Abdelrahman I Zain-AlabdeenDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.ORCID 0000-0001-9213-7191
Zainab M ElsayedScientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh Uinversity, Kafrelsheikh, Egypt.
Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Rofaida SalemDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0003-4262-0323
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.ORCID 0000-0001-6996-4017
Haytham O TawfikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.ORCID 0000-0001-6455-5716

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, new isatin-based sulphonamides (

Indexed as

Antineoplastic AgentsCarbonic AnhydrasesIsatinAntigens, NeoplasmCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXMolecular StructureStructure-Activity RelationshipSulfonamidesVascular Endothelial Growth Factor Receptor-2Antigens, NeoplasmAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesIsatinSulfonamidesVascular Endothelial Growth Factor Receptor-2antitumor agentsbiological activitiesmolecular dynamicsSynthesisVEGFR-2 inhibitors

Identifiers

PMID37122176
PMCPMC10134960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.