Evidence map›Paper›PMID 37122144›Full record

ReviewCNS neuroscience & therapeutics2023

Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms.

Yue Ma, Yingming Li, Run Yin, Peixin Guo, Nai Lei, Gang Li, Lei Xiong, Yuhuan Xie

Open access · goldAbstract readReview
In one paragraph

Review in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yue MaBasic Medical School, Yunnan University of Chinese Medicine, Kunming, China.ORCID 0000-0002-1935-3303
Yingming LiSchool of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China.
Run YinSchool of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China.
Peixin GuoCollege of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Nai LeiBasic Medical School, Yunnan University of Chinese Medicine, Kunming, China.
Gang LiBasic Medical School, Yunnan University of Chinese Medicine, Kunming, China.
Lei XiongBasic Medical School, Yunnan University of Chinese Medicine, Kunming, China.
Yuhuan XieBasic Medical School, Yunnan University of Chinese Medicine, Kunming, China.
Yunnan University · CNYunnan University of Traditional Chinese Medicine · CN

Funding

Understanding the neural mechanisms underlying the benefits of unitization on associative memory in young and older adultsR56AG070014 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DENNIS, NANCY ANNE · 2021 to 2021
$508k
NIA NIH HHS R56 AG070014
6 · The paper itself

Abstract

aimsThe aim of this review is to outline recent advancements in the application and mechanistic studies of aromatic plant extracts in Alzhermer`s disease (AD) to demonstrate their value in the management of this disease.

backgroundAD is a neurodegenerative disease with a complex pathogenesis characterized by severe cognitive impairment. Currently, there are very few drugs available for the treatment of AD, and treatments are primarily focused on symptom relief. Aromatherapy is a traditional complementary alternative therapy that focuses on the prevention and treatment of the disease through the inhalation or transdermal administration of aromatic plant extracts. Over the past few years, studies on the use of aromatic plant extracts for the treatment of AD have been increasing and have demonstrated a definitive therapeutic effect.

methodsWe systematically summarized in vitro, in vivo, and clinical studies focusing on the potential use of aromatic plant extracts in the treatment of AD in PubMed, ScienceDirect, Google Scholar, and the Chinese National Knowledge Infrastructure from 2000 to 2022.

resultsOur literature survey indicates that aromatic plant extracts exert anti-AD effects by modulating pathological changes through anti-amyloid, anti-tau phosphorylation, anti-cholinesterase, anti-inflammation, and anti-oxidative stress mechanisms (Figure 1).

conclusionThis review provides a future strategy for the research of novel anti-AD drugs from aromatic plant extracts.

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesHumansPlant ExtractsPlant ExtractsAlzheimer's diseasearomatic plant extractstherapeutic potentialunderlying mechanisms

Identifiers

PMID37122144
PMCPMC10352876
OpenAlexW4367554733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.